Clinical trial · Observational
Evaluation of the Expression and Prognostic Role of Tumor Stem Cell Marker SOX2 in Odontogenic Cysts and Tumors
Evaluation of the Prognostic Role of SOX2 as a Tumor Stem Cell Marker in Odontogenic Cysts and Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The pathogenesis of odontogenic lesions remains unclear; however, a probable explanation may involve the existence of tumor stem cells (TSCs), which are thought to generate both benign and malignant tumors. The preservation of stem cells during early dental development is governed by many transcription factors, including sex-determining region Y (SRY)-box 2 (SOX-2). Numerous studies observed the increased expression of SOX2 in various benign and malignant tumors, as its impact on tumorigenesis varies according to tumor type. The purpose of this study is to assess the immunoexpression of the stem cell marker SOX2 in diverse types of odontogenic cysts and tumors in order to identify its prognostic significance and to show if it correlates to clinicopathologic parameters of those odontogenic lesions.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Odontogenic Cysts | — | UNRESOLVED | — |
| Odontogenic Tumors | Odontogenic Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Ameloblastoma group
- description
- patients diagnosed with ameloblastoma
- label
- Odontogenic keratocyst group
- description
- patients diagnosed with Odontogenic keratocyst
- label
- Dentigerous cyst group
- description
- patients diagnosed with Dentigerous cyst
Primary outcomes (1)
- measure
- SOX2 staining score
- timeFrame
- 6 months
- description
- Semi-quantitative method for subjectively scoring the immunohistochemical staining. Positive specimens were considered when the nucleus had brown staining.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion criteria: 1\. Patients with benign odontogenic cysts and tumors which presented either in Maxilla or Mandible ( as indicated by incisional biopsies ) Exclusion criteria: 1. Patients with systemic diseases that absolutely contraindicate surgical procedures. 2. Malignant odontogenic tumors.
References
Publications (1)
- DERIVEDZeen El-Abdeen HM, Tawfik MA, Elnagdy SY, Mansour NA. Evaluation of the prognostic role of SOX2 as a tumor stem cell marker in odontogenic cysts and tumors: clinical, radiographic and immunohistochemical correlation. BMC Oral Health. 2025 Nov 1;25(1):1720. doi: 10.1186/s12903-025-07065-0. PMID 41176605