Clinical trial · Observational
ERAP1,2 in Recalcitrant Warts
Serum ERAP1 and ERAP2 Levels in Patients With Recalcitrant Warts
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The exact mechanisms underlying the contribution of cellular immunity in the eradication of human papillomavirus (HPV) infections remain obscure. Individuals who have treatment-resistant warts frequently have immune deficiencies. Amino-peptidases (ERAP1, ERAP2) of endoplasmic reticulum are essential for production of antigenic epitopes that attach to the Major Histocompatibility Complex (MHC) class I and activate T-lymphocytes or natural killer (NK) cells. Aim: To assess ERAP1 and ERAP2 serum concentrations in patients with resistant warts.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Warts | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| endoplasmic reticulum Aminopeptidase 1 and 2 | Diagnostic Test | — | UNRESOLVED |
| endoplasmic reticulum aminopeptidase 1 and 2 serum levels determination via ELISA | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- SERUM LEVELS OF endoplasmic reticulum aminopeptidase 1 and 2
- timeFrame
- ONE YEAR
- description
- using specific Commercial human ELISA kits
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: • Patients who had a history of incomplete clearance or recurrence following two or more electrocautery sessions and four or more cryocautery treatments and intralesional bleomycin. Exclusion Criteria: * Patients with genital warts * Patients on systemic steroids or other immunosuppressive treatments * Immunocompromised individuals * Patients suffering from chronic systemic diseases * Pregnant women
References
Publications (0)
Data not yet available