Clinical trial · Interventional
Efficacy of Propofol-Ketamine and Sevoflurane in Children Undergoing Magnetic Resonance Imaging
Comparison of the Efficacy of Intravenous Propofol-Ketamine and Sevoflurane Administered Via Face Mask in Children Undergoing Magnetic Resonance Imaging: A Prospective, Randomized, Parallel-Group Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Magnetic resonance imaging (MRI) is becoming increasingly important in the diagnosis and follow-up of pediatric diseases. However, successful MRI requires complete and prolonged immobility, which can be challenging for young children and infants. To overcome this challenge, various anesthesia techniques are employed by anesthesiologists. The ideal anesthesia method for children during MRI should be both safe and enable rapid recovery, allowing the child to remain still during the procedure while minimizing risks during the recovery period. \*\*Sevoflurane has become a popular choice for this purpose due to its rapid onset, limited respiratory side effects at low concentrations, reduced airway irritation, and hemodynamic stability. However, propofol and ketamine, used as an alternative sedation method, are also being increasingly utilized during these procedures. The major side effects of propofol include respiratory depression, apnea, loss of protective reflexes, and hemodynamic instability. To minimize these side effects, some experts recommend the combined use of propofol and ketamine. This combination provides effective sedation while also contributing to a reduction in side effects. In this context, the aim of our study is to compare the efficacy of intravenous propofol and ketamine with sevoflurane administered via a face mask during pediatric MRI.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hypoxemia | — | UNRESOLVED | — |
| Patient Safety | — | UNRESOLVED | — |
| Recovery Period | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ketamine | Drug | — | UNRESOLVED |
| Propofol | Drug | — | UNRESOLVED |
| Sevoflurane | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Group P
- description
- Intravenous propofol and ketamine will be administered to the patients in this group.
- interventionNames
- Drug: Propofol
- Drug: Ketamine
- type
- ACTIVE_COMPARATOR
- label
- Group S
- description
- Sevoflurane will be administered via a procedural oxygen mask to the patients in this group.
- interventionNames
- Drug: Sevoflurane
Primary outcomes (1)
- measure
- Recovery time
- timeFrame
- From the end of the MRI scan until the patient reaches a Ramsay Sedation Scale (RSS) score of 2, assessed for a maximum of 60 minutes.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 3 Months
- Maximum age
- 10 Years
Show eligibility criteria text
Inclusion Criteria: * Ages 3 months to 10 years. * Classified as ASA I-II according to the American Society of Anesthesiologists (ASA) classification. * Patients scheduled for MRI at Kocaeli City Hospital MRI unit. Exclusion Criteria: * Families or children who do not consent to participate in the study. * Patients with allergies to ketamine, propofol, midazolam, or sevoflurane. * Patients with known pulmonary or cardiac diseases. * Patients with known congenital craniofacial or neck anomalies. * Patients dependent on oxygen therapy. * Patients with a recent respiratory tract infection within the past 2 weeks. * Patients requiring tracheal intubation, laryngeal mask, or ventilator support. * Patients at risk of upper airway obstruction. * Patients with behavioral problems. * Patients with gastroesophageal reflux disease. * Patients with lethargy, stupor, or unresponsiveness to stimuli due to any cause * Patients with active use of antiepileptic or antipsychotic medications
References
Publications (2)
- BACKGROUNDSchmitz A, Weiss M, Kellenberger C, O'Gorman Tuura R, Klaghofer R, Scheer I, Makki M, Sabandal C, Buehler PK. Sedation for magnetic resonance imaging using propofol with or without ketamine at induction in pediatrics-A prospective randomized double-blinded study. Paediatr Anaesth. 2018 Mar;28(3):264-274. doi: 10.1111/pan.13315. Epub 2018 Jan 27. PMID 29377404
- BACKGROUNDOgurlu M, Orhan ME, Bilgin F, Sizlan A, Yanarates O, Yilmaz N. Efficacy of different concentrations of sevoflurane administered through a face mask for magnetic resonance imaging in children. Paediatr Anaesth. 2010 Dec;20(12):1098-104. doi: 10.1111/j.1460-9592.2010.03438.x. PMID 21199119