Clinical trial · Observational
Advances in Imaging to Assess Response in Rectal Cancer
Advances in Imaging to Assess Response in Rectal Cancer (AIR-REC)
NCT06822634CI-TRIAL-00085902AIR-RECrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to determine the feasibility of acquiring serial MRI images for advanced radiotherapy planning in colorectal patients. The main question it aims to answer: Is it feasible to acquire serial MR images for advanced radiotherapy planning for rectal cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer (CRC) | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Observational single centre feasibility study | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Colorectal cancer patients
- description
- Patients with histologically confirmed invasive rectal adenocarcinoma
- interventionNames
- Other: Observational single centre feasibility study
Primary outcomes (1)
- measure
- Feasibility of acquiring serial MRI for advanced radiotherapy planning of rectal cancer.
- timeFrame
- 18 months
- description
- Feasibility defined as 70% of study participants completing a baseline and repeat scan acquisition.
Secondary outcomes (4)
- measure
- Volumetric radiotherapy target volume data- longitudinal changes in radiotherapy target volume data measured in cubic centimetres
- timeFrame
- 18 Months
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed rectal adenocarcinoma. * T stage 3b or above and/or high risk factors eg. EMVI, nodal disease. * Participant able to give written informed consent. * Male or non-pregnant female ≥18 years of age. * Scheduled to undergo radical radiotherapy. * Patients willing and able to comply with the protocol for the duration of study. Exclusion Criteria: * Contra-indications to MRI, such as claustrophobia, excessive body weight, MRI unsafe implants, ferrous metal in the body, insufficient information on prior surgeries. MRI conditional implants where conditions cannot be met (e.g pacemakers). * Any previous radiotherapy to the pelvis. * Inflammatory bowel disease. * Other severe or uncontrolled systemic disease or evidence of any other significant disorder or lab finding that makes it undesirable for the patient to participate in the study, as determined by the treating clinician. * History of physical or psychiatric disorder that would prevent informed consent and compliance with the protocol. * Patients with de-functioning stoma. * Major surgery within 28 days prior to trial entry.
References
Publications (0)
Data not yet available
No reference posted for this study.