Biomarkers for Clinical Classification and Outcomes of Immune Checkpoint Inhibitor-Related-Related Myocarditis in Lung Cancer

Arms (2)

1. label

   Severe/critical group

   description

   Severe Type: Significant symptoms (e.g., fatigue, palpitations, chest pain) triggered by daily activities without hemodynamic changes; elevated myocardial biomarkers (Cardiac troponin, creatine kinase, Creatine kinase myocardial band, Aspartate aminotransferase，natriuretic peptides); new ECG changes; structural and functional myocardial abnormalities on echocardiography or MRI. Critical Type: Intolerable symptoms (e.g., respiratory dysfunction, heart failure, cardiogenic shock) at rest or minimal activity, with hemodynamic instability; significantly elevated myocardial biomarkers (Cardiac troponin, creatine kinase, Creatine kinase myocardial band, Aspartate aminotransferase, natriuretic peptides); severe myocardial structural and functional abnormalities on echocardiography or MRI; new severe arrhythmias on ECG .

   interventionNames

   1. Diagnostic Test: Biomarker Analysis for Severity Assessment

2. label

   Subclinical myocardial injury/mild group

   description

   Subclinical Myocardial Injury: All three of the following criteria must be met: 1. No clinical symptoms triggered by daily activities; 2. Only mild elevation of Cardiac troponin levels without elevation of other myocardial injury biomarkers; 3. No abnormalities detected in other auxiliary examinations. Mild Type: The following conditions must be met for diagnosis: 1. Daily activities may cause mild, nonspecific symptoms such as fatigue or shortness of breath; 2. Mild elevation of myocardial injury biomarkers (Cardiac troponin, creatine kinase, Creatine kinase myocardial band, Aspartate aminotransferase，natriuretic peptides); 3. Mild abnormalities on ECG, including new-onset sinus tachycardia, atrial arrhythmias, or nonspecific ST-T changes; 4. No structural or functional abnormalities of the myocardium detected by echocardiography or cardiac MRI.