Comparison Between Efficacy of Topical 25%Podophyllin and Cryotherapy on Genital Warts

Human papilloma virus (HPV), is the major prevalent cause of sexually transmitted disease affecting genitalia, causing Condylomata Accuminata, also known as external genital warts or anogenital warts.¹ Occurring in men and women with a prevalence rate of 0.6-1.2% worldwide. It primarily affects those in the age range of 20-25 years. Human papilloma virus infections subclinically are primarily caused by either type HPV- 6 or HPV- 11. A vast variety of treatment options are available to treat CA , including immunomodulators ( imiquimod, purified protein derivative and the HPV vaccine), physical ablation ( cryotherapy and electrodessication) and topical cytotoxic drugs ( TCA, phenol, 5- fluorouracil, retinoids, podophyllin and bleomycin)¹ . Although there are multiple effective treatment are present for EGW, no single treatment has been identified as the best ideal way to treat CA. Cryotherapy causes the destruction of keratinocytes infected with HPV by using below zero temperature and leading to thermal cell necrosis. Podophyllum peltatum and Podophyllum emodi are the main source of Podophyllin, a refined plant- based resin.¹² It works by attaching itself to the infected cell's microtubule disturbing the linking process which stops the mitotic process during the metaphase stage of cell division causing the death of epithelial cell. Study will include patients which will be divided into 2 groups A \& B, 48 in each group. Group A will receive topical 25% podophyllin resin via cotton bud under supervision once weekly for 04 weeks. Group B will receive cryotherapy of 10sec freeze cycle twice weekly for 04 weeks. Patient will be followed at interval of 4 weeks and 8 weeks from start of treatment. Treatment will be considered efficant when decrease in the number of warts is clinically evident at follow up visits. Efficacy of treatment will be graded as 'excellent' \>90% clearance, 'good'60-89% clearance, 'satisfactory'30-59% clearance and 'poor'\<30% clearance.

Sex

All

Minimum age

16 Years

Maximum age

60 Years

Inclusion Criteria:

* Age: 16-60years
* Gender: Any gender
* All new clinically diagnosed cases of plane warts
* Type of warts: plane warts
* Area: Ano-genital warts
* Size: Less than 10cm2(cummulative)
* No. of warts: Upto 20
* Duration of disease: Any

Exclusion Criteria:

* Pregnancy and lactating females
* Bleeding disorders
* Immunocompromised patients.
* Diabetic patients / Peripheral vascular disease.
* Bleeding warts, moles, birthmarks.
* Any other inflammatory dermatosis on that area
* History of any previous treatment in last 2 months.
* Liver/Renal disease
* Hypersensitivity to Podophyllin.