Clinical trial · Observational
Prognostic Value of PARS Classification for Locally Recurrent Rectal Cancer
Prognostic Value of PARS Classification in Predicting Post-recurrent Survival for Locally Recurrent Rectal Cancer Patients Undergoing Salvage Radical Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this retrospective study was to explore the predictors of post-recurrent survival in locally recurrent rectal cancer patients undergoing salvage radical surgery. Based on the identified risk factors, investigators propose a new risk stratification to facilitate the development of strategies for surgical treatment and follow-up care.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Local Recurrence of Malignant Tumor of Rectum | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- PARS Type I
- description
- Patients with central recurrence who had zero or one PHF were classified as PARS Type I.
- label
- PARS Type II
- description
- Patients with central recurrence who had two and more PHFs were classified as PARS Type II. Central recurrences with two and more PHFs and non-central recurrences with no PHF were also classified as PARS Type II.
- label
- PARS Type III
- description
- Patients with non-central recurrence who had one and more PHF were classified as PARS Type III
Primary outcomes (1)
- measure
- PRS
- timeFrame
- PRS was calculated from the date of salvage radical surgery until the date of death or until censored at the last follow-up, assessed up to 140 months.
- description
- Post-recurrent survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * (1) the primary tumor was located in the sigmoid colon or rectum, following prior radical tumor resection; * (2) local recurrence was confirmed through CT, MRI, and serum cancer biomarker test, or endoscopic biopsy; * (3) the recurrent site was confined to the pelvis; * (4) the recurrent tumor underwent R0 or R1 surgical resection; * (5) the absence of uncontrollable distant metastases at the time of salvage radical surgery. Exclusion Criteria: * (1) patients with unresectable tumors identified before salvage radical surgery, leading to palliative therapy; * (2) a recurrence interval of less than three months; * (3) incomplete baseline characteristics, including pathologic data from the initial treatment; * (4) loss to follow-up.
References
Publications (0)
Data not yet available