Clinical trial · Interventional
Urine Methylation Markers in UTUC
Urine-based Methylation Markers in the Diagnosis and Surveillance of Upper Tract Urothelial Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a research study to measure DNA markers in the urine of patients with upper tract urothelial cancer (UTUC) before surgery and during follow-up visits. Identifying these DNA markers could improve diagnosis before surgery, help assess risk, and predict early recurrence of the cancer. Urine samples will be de-identified and sent to Pangea Laboratory LLC for analysis. The results of this test will be compared to the traditional tests in upper tract urothelial cancer, such as cells in the urine and tissue biopsy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Upper Tract Urothelial Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Bladder CARE™ | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Patients with primary UTUC (upper tract urothelial carcinoma)
- description
- Urine DNA samples will be quantified using Bladder CARE™ at baseline, 3 months, and 6 months.
- interventionNames
- Diagnostic Test: Bladder CARE™
Primary outcomes (3)
- measure
- Methylation level of urothelial-specific biomarker TRNA-Cys
- timeFrame
- Baseline, 3 months, 6 months
- measure
- Methylation level of urothelial-specific biomarker SIM2
- timeFrame
- Baseline, 3 months, 6 months
- measure
- Methylation level of urothelial-specific biomarker NKX1-1
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * \>=18 years * Primary UTUC Exclusion Criteria: * Patients who do not understand and/or are unwilling to sign a written informed consent
References
Publications (0)
Data not yet available