Clinical trial · Observational
Craniopharyngioma and Pregnancies
Description of Pregnancies and Their Impact on the Craniopharyngioma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Craniopharyngiomas (CP) are rare hypothalamic-pituitary tumors found in young children, adolescents and adults. The management of PC remains complex, as their aggressive nature, invasive behavior and propensity to recur require sequential and balanced therapeutic attitudes, as well as follow-up in an expert center. Although patient survival rates are high, the consequences of the tumor and its treatment can lead to serious comorbidities and impaired quality of life, particularly in patients whose tumors extend to the hypothalamus. There is very little literature describing the outcome of pregnancy in craniopharyngioma patients and its impact on the craniopharyngioma. The largest study describes 6 women, mean age 24, who had a craniopharyngioma in childhood. Half of them had induced pregnancies; there is a succinct description of pregnancy complications and outcomes, as well as tumor progression. In the endocrinology department of Pitié Salpêtrière hospital, the investigators regularly follow over a hundred patients of all ages who have presented with a craniopharyngioma in childhood or adulthood. They are also unique in having a medically assisted reproduction unit, which helps couples to realize their parental project. This dual specialization will enable to describe pregnancies and their impact on the behavior of craniopharyngiomas.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Craniopharyngioma | Craniopharyngioma | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Questionnaire | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Describe how pregnancies are obtained: spontaneous or induced (and by which assisted reproduction technique).
- timeFrame
- 12 months
- description
- Information on how the pregnancy was obtained will be collected from the medical record and will be completed on the day of inclusion by a telephone questionnaire with the patient.
Secondary outcomes (7)
- measure
- Describe the existence of a parental project among the women in the cohort
- timeFrame
- 12 months
- description
- Information on the existence of a parental project will be completed on the day of inclusion by a telephone questionnaire with the patient.
- measure
- Describe obstetric outcomes
- timeFrame
- 12 months
- description
- Describe obstetric outcomes from the informations obtained during the telephone questionnaire, and pregnancy/childbirth reports.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged at least 18 years old * Patients with or having had a craniopharyngioma * Patients informed and not opposed to participation in research Exclusion Criteria: * Patients who don't speak french * Patients without medical care insurance * Patients under legal protection
References
Publications (0)
Data not yet available