Clinical trial · Interventional
Periodontal Disease and Colorectal Cancer
The Influence of Periodontal Disease and Periodontal Treatment on Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The aim of this interventional study is to determine the impact of periodontal disease and periodontal treatment on patients with colorectal cancer. The main questions were: 1. Does periodontal treatment affect the levels of C-reactive protein in the blood of patients undergoing cancer treatment? 2. Can the investigators isolate periodontal pathogenic bacteria Fusobacterium nucleatum and Porphyromonas gingivalis from the mucosa of cancerous colon tissue using the method of quantitative culture? The investigators will compare the levels of C-reactive protein in the blood of patients undergoing treatment for colorectal cancer who have received periodontal treatment with patients who have not received periodontal treatment. CRP levels will be measured during the first examination with the oncological surgeon, on the first and second day after the surgical procedure, and during the first follow-up with the oncological surgeon. Additionally, the investigators collected samples of cancerous colon mucosa from 10 participants for the attempt to isolate F. nucleatum and P. gingivalis using the quantitative culture method.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Carcinoma | Colorectal Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Periodontal Diseases | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| periodontal treatment | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Patients with colorectal cancer who recived periodontal treatment
- description
- Patients with colorectal cancer were treated for periodontal disease based on the condition of their periodontal tissues.
- interventionNames
- Procedure: periodontal treatment
- type
- NO_INTERVENTION
- label
- Patients with colorectal cancer who did not recived periodontal treatment
- description
- Due to ethical concerns, we selected patients who had completed cancer therapy before the start of our study for the control group, and who met the inclusion criteria based on the completed questionnaires.
Primary outcomes (2)
- measure
- CRP levels
- timeFrame
- From the enrollment to the date of first documented progression at 16 weeks
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * colorectal cancer, scheduled for surgical treatment * consent to participate Additional inclusion Criteria fot the control group: * fiilled questionnaire * Recorded CRP results at the first examination, after surgery, and at the first follow-up examination. Exclusion Criteria: * under 18 years old * periodontal treatment in the past 12 months * antibiotic therapy in the last 3 months * edentulism * advanced stage cancer, scheduled for palliative care * chemotherapy or radiotherapy prior to surgical procedure
References
Publications (1)
- DERIVEDRebersak UP, Brecelj E, Schara R. The influence of periodontal disease and periodontal treatment on colorectal cancer. Radiol Oncol. 2025 Dec 16;59(4):589-596. doi: 10.2478/raon-2025-0025. eCollection 2025 Dec 1. PMID 40272186