Clinical trial · Interventional
Loop Resection or Cold-cup Biopsy? A Study Comparing the Accuracy of Muscle Samples During Bladder Tumor Surgery
Loop Resection or Cold-cup Biopsy? A Prospective Randomized Study Evaluating the Accuracy of Detrusor Muscle Representation During Transurethral Resection of Bladder Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this report the investigators compared two deep muscle sampling methods (Loop resection and Cold-Cup Biopsy) during endoscopic resection of bladder tumors for patients with suspected bladder cancer in Tygerberg hospital. The investigators found that both sampling methods are equal effective with regards to muscle representation, regardless of surgeon experience. An important finding is that Loop Resection produced less tissue artefacts in the deep muscle specimen for the more experienced surgeons, while there was no difference for less experienced surgeons. The investigators thus conclude that - from a practical point of view - Loop Resection should be the deep muscle sampling method of choice.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Cancer | Malignant Bladder Neoplasm | CURATED_EXACT | 0.92 |
| Bladder Cancer Stage I | Malignant Bladder Neoplasm | CURATED_BROADER | 0.78 |
| TURBT | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Loop Resection or Cold-cup biopsy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Cold-Cup Biopsy
- description
- Cold-Cup Biopsy of bladder tumor base
- interventionNames
- Procedure: Loop Resection or Cold-cup biopsy
- type
- EXPERIMENTAL
- label
- Loop Resection of bladder tumor base
- description
- Loop Resection of bladder tumor base
- interventionNames
- Procedure: Loop Resection or Cold-cup biopsy
Primary outcomes (1)
- measure
- Detrusor Muscle Representation
- timeFrame
- From enrollment to the end of treatment at 2-4 weeks when histology results are available
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * • All patients requiring cystoscopy plus loop resection of bladder tumor. Exclusion Criteria: * • Patients who underwent cystoscopy and no loop resection * Patients who underwent cystoscopy and only cold-cup biopsy
References
Publications (0)
Data not yet available