Clinical trial · Observational
STRatifying Adult DIffuse Lower-grade Gliomas Based on Their VARIed Metabolic Profiles (STRADIVARI Project)
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to better characterise lower-grade gliomas from a molecular and metabolic point of view, so to identify further subgroups of these tumours with different behaviour and, possibly, different treatment susceptibility. Participants of prospective metabolic cohort will be subjected to routine treatment, part of the exceeding tutor material will be subjected to advanced molecular-metabolic analyses to desume their metabolic profile to be then correlated with clinical outcome (progression-free survival, overall survival, response to therapy/progression) and diagnosis (astrocytoma/oligodendroglioma and grade). Critical enzymes identified from metabolic analyses on the first cohort will be tested on a protein level on a retrospective cohort of patients previously operated and for whom fully available clinical history and pathological material is available in Institutional archive (no need for further intervention on these patients) to see if they actually correlate with clinical outcome.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lower Grade Glioma | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Prospective Metabolic Cohort
- description
- Patients operated on for lower grade gliomas from whom part of the exceeding pathologic material will be collected for metabolomic profiling
- label
- Retrospective FFPE Sample Cohort
- description
- Historical patient cohort for whom FFPE sections, full clinical history and pathological data are available.
Primary outcomes (2)
- measure
- Progression Free Survival (PFS)
- timeFrame
- (up to 180 months)
- description
- time from surgery to evidence of radiological progression at MRI
- measure
- Overall Survival (OS)
- timeFrame
- (up to 180 months)
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Prospective Metabolic Cohort: Inclusion Criteria: * Radiological diagnosis of brain tumor compatible with lower grade glioma * Full clinical history Exclusion Criteria: * Current pregnancy or lactation * Patients not able to provide informed consent Retrospective Cohort of FFPE samples: Inclusion Criteria: * Confirmed diagnosis of lower grade glioma * Full clinical and radiological history
References
Publications (0)
Data not yet available