Clinical trial · Observational
MEASUREMENT OF CIRCULATING MUTATION BURDEN
EVALUATION OF CANCER RISK BY MEASUREMENT OF CIRCULATING MUTATIONAL BURDEN IN CARRIERS OF A GENETIC PREDISPOSITION
NCT06792721CI-TRIAL-00091833cRISKrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cancer-free women with a hereditary predisposition to breast and/or ovarian cancer
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| BRCA Mutation | — | UNRESOLVED | — |
| Breast Carcinoma | Breast Carcinoma | ONTOLOGY_EXACT | 0.98 |
| cfMB | — | UNRESOLVED | — |
| Genetic Predisposition to Cancer | Breast Neoplasm | PROBABILISTIC | 0.70 |
| Mutation Burden | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mutation Burden cfMB analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Case group
- description
- participant with a hereditary predisposition linked to a BRCA1/2 mutation (case)
- interventionNames
- Genetic: Mutation Burden cfMB analysis
- label
- Control group
- description
- participant not carrying a hereditary predisposition linked to a BRCA1/2 mutation (control) participant from the same sibling as the carrier participant (sister)
- interventionNames
- Genetic: Mutation Burden cfMB analysis
Primary outcomes (1)
- measure
- Comparing the mutational burden in a person genetically predisposed to cancer with that of a non-predisposed relative
- timeFrame
- At the enrollment in the study (one point)
- description
- Measurement and quantification of genomic signature on circulating DNA (mutational burden) derived from whole blood in a carrier of the genetic mutation and in her non-carrier first-degree relative.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Female participant * Participant undergoing oncogenetic follow-up at the Centre François Baclesse * Participant belonging to a pair of related biological siblings * Within the sibling pair, one participant is a carrier of a hereditary predisposition linked to a BRCA1/2 mutation (case), and the other participant is not a carrier (control). * Participant between 30 and 50 years of age * Participant affiliated to a social security scheme * Participant having given her consent to participate by signing an informed consent form prior to any specific study-related procedure. Exclusion Criteria: \-
References
Publications (0)
Data not yet available
No reference posted for this study.