Clinical trial · Interventional
Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers and Mental Health.
Managing Hepatitis B (Hep. B) and Human Papilloma Virus (HPV) Related Cancers Among Women of Childbearing Age, and Young Adults in Zimbabwe in the Context of Mental Health: a Multimodal, Multifaceted Approach.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Aim: The main goal of this quantitative epidemiological observational study is to determine the prevalence of Human Papilloma Virus (HPV) infection and Hepatitis B (Hep B) immunity amongst women of childbearing age. attending clinics at Mtshabezi Mission and Matobo clinic respectively, and assessing behavioral risk factors of high school students at these catchment areas that can put them at risk for developing cancer of the cervix and liver. Question: Can screening for cancer, vaccination against Hep B and HPV, and cognitive behavior intervention help in preventing related cancers amongst these groups of participants?
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Liver | — | UNRESOLVED | — |
| Cancer of Cervix | Malignant Cervical Neoplasm | ALIAS | 0.90 |
| Depression, Anxiety | — | UNRESOLVED | — |
| Hepatitis B | — | UNRESOLVED | — |
| Human Papilloma Virus | — | UNRESOLVED | — |
| Mental Health Issue | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cognitive Behavioral Therapy | Behavioral | — | UNRESOLVED |
| Gardasil 9 vaccine | Biological | — | UNRESOLVED |
| Hepatitis B Virus Vaccine(HBV) | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- High School Students
- description
- All high school students in the study area are eligible, approximately 1000 students. Consenting participants will complete a one-time Youth Risk Behavior Survey (CDC) and receive Cognitive Behavioral Therapy if indicated. Eligible and consenting participants will be offered a 3-dose series of Gardasil 9 to protect against HPV.
- interventionNames
- Biological: Gardasil 9 vaccine
- Behavioral: Cognitive Behavioral Therapy
- type
- OTHER
- label
- Women of childbearing age and young adults (13-50years old)
- description
- This group is at highest risk for having exposure to cervical and liver cancer, depression and anxiety. Participants are unlikely to have had vaccines of interest, Hep B, and HPV, as their status is unknown due to a lack of screening and vaccination. Participants in this group with depressive/anxiety symptoms are likely to benefit from CBT intervention
- interventionNames
- Biological: Gardasil 9 vaccine
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 13 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * For the High school students' group: All students aged 13 years and older, enrolled at the selected Mtshabezi and Matopo High Schools in the Gwanda and Matobo Rural Districts during the five years of the project, are eligible to participate in the study. Ability to understand and respond to questions on the Youth Risk Behavior Survey questionnaire and PHQ-9 scale. Relevant history of HPV vaccine administration. Ability to obtain parental/guardian consent for participation. \- For the women's group: All women and young female adults, thirteen to fifty years old, and requesting health services for prenatal, post-partum, family planning, and other care during the five-year project period are eligible to participate. Can understand and respond to the PHQ-9 and Edinburgh Postnatal Depression scales. Must have a valid consent for participation in the study. Exclusion Criteria: * males who are not enrolled in these participating High Schools. * children below the age of thirteen who are not enrolled in high schools and are not seeking prenatal, post-partum, and family planning services at these selected health facilities during the project period. * Any eligible potential participant without a valid consent. * Any potential participant who is excluded by a doctor or midwife for a known contraindicating medical condition that can lead to potential harm to the participant or staff. Any potential participant who is unable to understand and respond to the questions being asked.
References
Publications (0)
Data not yet available