Clinical trial · Interventional
Differences in Gastric Microbiota in Patients Who Were Infected Between CagA Positive and Negative Helicobacter Pylori
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to study the differences in gastric microbiota (Diversity index) between patients who were infected with CagA-positive Helicobacter pylori and CagA-negative Helicobacter pylori. The main question it aims to answer are: The effect of Helicobacter pylori typing (CagA status) on gastric microbiota, what is the different? Patients indicated for EGD at Siriraj Endoscopic Center will undergo a Helicobacter pylori test (Rapid urease test) If the result is positive, a stomach biopsy for gastric microbiota testing and CagA antibody testing will be conducted. Then, the patients will be divided into two groups: CagA-positive Helicobacter pylori and CagA-negative Helicobacter pylori. To compare the differences in gastric microbiota in terms of species and biodiversity, as well as endoscopic results, etc.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| CagA | — | UNRESOLVED | — |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Microbiota | — | UNRESOLVED | — |
| Helicobacter Pylori | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Stomach biopsy for gastric microbiota | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- OTHER
- label
- CagA positive H.pylori
- description
- CagA positive H.pylori
- interventionNames
- Procedure: Stomach biopsy for gastric microbiota
- type
- OTHER
- label
- CagA negative H.pylori
- interventionNames
- Procedure: Stomach biopsy for gastric microbiota
Primary outcomes (1)
- measure
- The differences in gastric microbiota (Diversity index)
- timeFrame
- On the 1 day of EGD
- description
- Diversity index: Shannon index, Simpson index
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged over 18 with an indication for EGD * Helicobacter pylori infection (Rapid urease test positive) Exclusion Criteria: * Severe comorbidities: poorly controlled DM, ESRD, decompensated cirrhosis, Malignancy * BMI ≤ 23 kg/m2 * Receiving medications that affect the gastric microbiota include Antibiotics, probiotics, or bismuth within 4 weeks, PPI within 2 weeks, NSAIDs or Metformin within 2 weeks * History of cholecystectomy or proximal small bowel surgery
References
Publications (0)
Data not yet available