Clinical trial · Observational
Prognostic Significance of the Lung Immune Prognostic Index (LIPI) in Postoperative Clear Cell Renal Cell Carcinoma: a Multicenter Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This retrospective study included 704 patients with ccRCC who underwent radical or partial nephrectomy. Patients were stratified into the LIPI good group and the intermediate/poor (int./poor) group based on dNLR (≥ 3) and LDH (≥ 245 U/L) levels. Propensity score matching (PSM) was used to adjust for baseline differences and minimize selection bias. Kaplan-Meier survival curves and Cox regression models were employed to evaluate the impact of LIPI and other clinical factors on recurrence-free survival (RFS) and overall survival (OS).
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| ccRCC | Clear Cell Renal Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Cohort 1
- description
- Patients with dNLR \< 3 and LDH levels below the upper limit of normal
- label
- Cohort 2
- description
- Patients with dNLR ≥ 3 and LDH levels above the upper limit of normal
Primary outcomes (2)
- measure
- overall survival (OS)
- timeFrame
- 5 years
- measure
- recurrence-free survival (RFS)
- timeFrame
- 5 years
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Pathologically diagnosed with ccRCC; 2. Underwent radical or partial nephrectomy. Exclusion Criteria: 1. presence of concurrent malignancies; 2. missing data or failure to follow-up
References
Publications (1)
- DERIVEDPan Z, Li Y, Lou J, Shan S, Guo Y, Jiang S, He Q, Zhou G, Yang L. Preoperative lung immune prognostic index (LIPI) predicts postoperative outcomes in clear cell renal cell carcinoma: a multicenter study. Sci Rep. 2026 May 25;16(1):23900. doi: 10.1038/s41598-026-54219-3. PMID 42185427