Clinical trial · Observational
Cancer Prevalence and Outcomes in Individuals With HIV and AIDS: Multicenter BUHASDER Study
Cancer Prevalence and Outcomes in Individuals Living With HIV and AIDS: Multicenter BUHASDER Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
AIDS-defining cancers reported a 70% drop in the 1990s following the advent of triple antiretroviral therapy in the USA. With increased survival, the proportion of non-AIDS-defining cancers increases with age, making cancer a leading cause of death among individuals with HIV infection in developed countries, with higher cancer-related mortality rates in this group. In Turkey, studies have reported HIV-associated non-Hodgkin lymphoma cases, and a multicentre study documented 37 cancer cases from 1998 to 2016. This study aims to determine the prevalence of cancer in individuals with HIV and AIDS in Turkey over the past decade, examining the age-related distribution and risk factors for HIV-related and unrelated cancers. Additionally, the mortality rates and comorbidities affecting mortality will be assessed. The findings will be compared with the Turkish Statistical Institute's data on cancer prevalence, type, and mortality.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Hiv | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- HIV&Malignancy
- description
- All AIDS-defining and non-defining cancers in individuals living with HIV
Primary outcomes (2)
- measure
- Prevalence and risk factors of cancer in individuals living with HIV and AIDS
- timeFrame
- Medical records of individuals living with HIV who were diagnosed with cancer between November 1, 2014, and November 1, 2024, will be reviewed starting on November 12, 2024. Patients will be enrolled in the study beginning on November 12, 2024.
- description
- This outcome measure aims to determine the prevalence of cancer in individuals living with HIV and AIDS in Turkey, including age-related distribution and cancer types. Measurement Tool/Method: Cancer prevalence will be assessed through retrospective analysis of patient records and registry data. Unit of Measure: Percentage of individuals diagnosed with cancer.
- measure
- Risk Factors of Cancer in Individuals Living with HIV and AIDS
- timeFrame
- Medical records of individuals living with HIV who were diagnosed with cancer between November 1, 2014, and November 1, 2024, will be reviewed starting on November 12, 2024. Patients will be enrolled in the study beginning on November 12, 2024.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients over 18 years of age 2. All patients with HIV seropositivity and concurrent pathology-confirmed cancer diagnosis Exclusion Criteria: 1. Pediatric patients 2. Patients who do not attend follow-up visits and do not adhere to treatment
References
Publications (5)
- BACKGROUNDYarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018 Mar 15;378(11):1029-1041. doi: 10.1056/NEJMra1615896. PMID 29539283
- BACKGROUNDCoghill AE, Han X, Suneja G, Lin CC, Jemal A, Shiels MS. Advanced stage at diagnosis and elevated mortality among US patients with cancer infected with HIV in the National Cancer Data Base. Cancer. 2019 Aug 15;125(16):2868-2876. doi: 10.1002/cncr.32158. Epub 2019 May 3. PMID 31050361
- BACKGROUNDSomay K, Copur S, Osmanbasoglu E, Masyan H, Arslan H, Akay OM, Tekin S, Ferhanoglu B. HIV-ASSOCIATED NON HODGKIN LYMPHOMA: A CASE SERIES STUDY FROM TURKEY. Afr J Infect Dis. 2020 Jul 31;14(2):42-47. doi: 10.21010/ajid.v14i2.7. eCollection 2020. PMID 33884350
- BACKGROUNDAydin OA, Gunduz A, Sargin F, Mete B, Karaosmanoglu HK, Sevgi DY, Yemisen M, Durdu B, Dokmetas I, Tabak F; ACTHIV-IST (Action Against HIV in Istanbul) Study Group. Prevalence and mortality of cancer among people living with HIV and AIDS patients: a large cohort study in Turkey. East Mediterr Health J. 2020 Mar 24;26(3):276-282. doi: 10.26719/emhj.19.030. PMID 32281636
- DERIVEDGuler O, Akhan S, Cagatay A, Batirel A, Sargin Altunok E, Bolukcu S, Ozkan Ozdemir H, Duman EI, Toygar Deniz M, Ozyigitoglu D, Ozden K, Alay H, Seyman D, Turken M, Calik S, Caydasi O, Ozturk Engin D, Gunal O, Topal S, Karabay O, Sarigul F, Karakoc Parlayan HN, Kilinc Toker A, Aydin O, Bayhan E, Ergen P, Ince N, Kaya S, Arslan Ozel S, Ozsahin A, Gurbuz E, Sahin A, Balci S, Kose S. Cancer prevalence and prognosis among individuals living with HIV and AIDS in Turkey: Multicenter BUHASDER study. Int J STD AIDS. 2026 Apr;37(5):500-510. doi: 10.1177/09564624251405965. Epub 2025 Dec 7. PMID 41353610