Onco-Vascular Exer-Study

In Chile, in the year 2022, the main causes of death were diseases of the circulatory system (31,606) and cancer (with 28,453 deaths). Both causes of death came from diseases such as arterial hypertension, diabetes, and obesity, all highly associated to sedentary lifestyle (i.e., spending long hours sitting), physical inactivity (i.e., not adhering to international recommendations of physical activity per week of 150 to 300 min of low to moderate intensity physical activity, or 75 to 150 min of vigorous physical activity per week) and others risk factors (i.e., healthy eating, and inflammation processes such as cancer). Worryingly, in the Bío-Bío, Chile region, women's deaths from cancer reported 1,380 deaths, one of the highest disease mortality in this country. On the other hand, exercise training (i.e., defined as a particular type of physical activity guided by a professional and regulated overtime) has demonstrated evidence to the prevention and treatment of cancer, as well as in diabetes and arterial hypertension (co-morbidities). This benefits of exercise training has been raised by the American College of Sports Medicine (ACSM), emphasizing the evidence in favor of the exercise training (i.e., particularly aerobic/moderate-intensity continuous and resistance-type exercise) from the strongest (anxiety, depression, fatigue, quality of life, lymphedema, physical function) to the least amount of evidence (cardio-vascular, pain, etc) benefits on cancer survivors. However, there is scarcity of knowledge about the effects of other exercise modalities such as concurrent training on cardiovascular, metabolic and physical fitness of adul woman breast cancer survivors.

Sex

Female

Minimum age

30 Years

Maximum age

75 Years

Inclusion Criteria:

* Breast cancer diagnosed
* With/without chemotherapy treatment
* Normal weight body mass index \[BMI\] 18.6 to 24.9 or overweight/obesity condition by BMI 25.0 to 39.9 kg/m2
* Age 30 to 75 years
* With/without other associated co-morbidities (diagnosed of elevated fasting glucose, prediabetes or diabetes, hypertension or prehypertension, or metabolic syndrome, fatty liver or hypercholesterolemia or screened by our research team).
* With/without hormonal therapy
* With/without other pharmacotherapy for specific muscle-groups such as morphine patches, morphine droplets or other pharmacological therapy for SOS pain treatment

Exclusion Criteria:

* History of abnormal ECG
* Diagnosis of other cardio-vascular condition/history other than hypertension, vasculopathy
* History of uncontrolled stage 3 of hypertension or hypertensive crisis
* Diabetes complications such as varicose ulcers, nephropathies
* Skeletal muscle abnormalities (e.g., knee, or hip arthrosis, muscle pain)
* Using weight loss treatment/pharmacotherapy or being active in exercise training programs (or within the past three months)
* Use other pharmacotherapy that can influence body weight loss,
* Respiratory disease type (chronic obstructive disease)
* Kidney disease
* Pregnancy
* Smoking behaviour or dependence on other substances.