Clinical trial · Interventional
Composite Warming Strategy Reduces Intraoperative Hypothermia in Open Hepatectomy for Liver Cancer
Warming With a Composite Warming Strategy Reduces Intraoperative Hypothermia in Patients Undergoing Open Hepatectomy for Liver Cancer: A Randomized Controlled Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The composite warming strategy has a certain effect on preventing hypothermia during cancer liver resection surgery. This study aims to explore the application of compound warming strategy in perioperative nursing of cancer liver resection. This study will compare two groups: the control group using perioperative forced warming measures, and the experimental group using a composite warming strategy. Main objective: Intraoperative temperature changes Secondary objective: incidence of complications The investigators' investigated the practicality and effectiveness of a combined warming strategy in open liver resection surgery. In addition, the investigators also conducted a quantitative correlation study on the incidence of hypothermia during the surgical process. This provides evidence-based guidance for the prevention of hypothermia during surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HCC | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Compound heating strategy | Procedure | — | UNRESOLVED |
| perioperative mandatory warming measures | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Control group: perioperative mandatory warming measures
- interventionNames
- Procedure: perioperative mandatory warming measures
- type
- EXPERIMENTAL
- label
- Compound heating strategy
Primary outcomes (1)
- measure
- Intraoperative temperature changes
- timeFrame
- At the beginning of the surgery; every 5 minutes during surgery; after the surgery is completed.
- description
- Intraoperative temperature changes: After the surgery begins, a temperature monitoring device (disposable medical temperature sensor provided by the limited company) is inserted into the patient's nasopharynx to record the core temperature, while activating the water blanket and forced air.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Aged between 18 and 75 years. * Scheduled for elective open hepatectomy to treat hepatocellular carcinoma, confirmed by preoperative biopsy or imaging. * Adequate liver function (Child-Pugh score A or B). * American Society of Anesthesiologists (ASA) physical status classification of I, II, or well-controlled III. * Informed consent provided for participation. Exclusion Criteria: * Aged under 18 or over 75 years. * Metastatic liver disease or emergency liver surgery required. * Chronic analgesic use that could interfere with pain assessment. * Participation in another clinical trial within the past 30 days. * Contraindications to warming devices (e.g., certain skin conditions or advanced peripheral vascular disease). * Pregnant or lactating. * Presence of an implantable device (e.g., pacemakers or defibrillators) that could be affected by warming strategies. * Cognitive impairment or psychiatric disorders affecting study understanding or informed consent. * Use of medications/substances impacting thermoregulation (e.g., illicit drugs, alcohol abuse, antipyretics). * History of malignancies other than liver cancer affecting survival or perioperative risk. * Recent history (within six months) of myocardial infarction or cerebrovascular accident. * Uncontrolled diabetes mellitus or other significant endocrine disorders. * Severe anemia (hemoglobin below a predetermined threshold).
References
Publications (11)
- RESULTJohn M, Ford J, Harper M. Peri-operative warming devices: performance and clinical application. Anaesthesia. 2014 Jun;69(6):623-38. doi: 10.1111/anae.12626. Epub 2014 Apr 10. PMID 24720346
- RESULTAndrzejowski J, Hoyle J, Eapen G, Turnbull D. Effect of prewarming on post-induction core temperature and the incidence of inadvertent perioperative hypothermia in patients undergoing general anaesthesia. Br J Anaesth. 2008 Nov;101(5):627-31. doi: 10.1093/bja/aen272. Epub 2008 Sep 26. PMID 18820248
- RESULTKvolik S, Jukic M, Matijevic M, Marjanovic K, Glavas-Obrovac L. An overview of coagulation disorders in cancer patients. Surg Oncol. 2010 Mar;19(1):e33-46. doi: 10.1016/j.suronc.2009.03.008. Epub 2009 Apr 25. PMID 19394816
- RESULTKanikarla Marie P, Fowlkes NW, Afshar-Kharghan V, Martch SL, Sorokin A, Shen JP, Morris VK, Dasari A, You N, Sood AK, Overman MJ, Kopetz S, Menter DG. The Provocative Roles of Platelets in Liver Disease and Cancer. Front Oncol. 2021 Jul 21;11:643815. doi: 10.3389/fonc.2021.643815. eCollection 2021. PMID 34367949
- RESULTStaikou C, Paraskeva A, Drakos E, Anastassopoulou I, Papaioannou E, Donta I, Kontos M. Impact of graded hypothermia on coagulation and fibrinolysis. J Surg Res. 2011 May 1;167(1):125-30. doi: 10.1016/j.jss.2009.07.037. Epub 2009 Aug 26. PMID 19932906
- RESULTBirgin E, Kaslow SR, Hetjens S, Correa-Gallego C, Rahbari NN. Minimally Invasive versus Open Liver Resection for Stage I/II Hepatocellular Carcinoma. Cancers (Basel). 2021 Sep 25;13(19):4800. doi: 10.3390/cancers13194800. PMID 34638285
- RESULTXu H, Xu G, Ren C, Liu L, Wei L. Effect of forced-air warming system in prevention of postoperative hypothermia in elderly patients: A Prospective controlled trial. Medicine (Baltimore). 2019 May;98(22):e15895. doi: 10.1097/MD.0000000000015895.