Clinical trial · Observational
Analgesia Nociception Index (ANI) in Intracranial Surgical Anesthesia
Evaluation of Analgesia Nociception Index Monitoring in Intracranial Surgery Anesthesia
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In our study, 75 patients aged 18-80 years, classified as ASA I-II risk groups, who underwent intracranial surgery performed by the Department of Neurosurgery at Trakya University Faculty of Medicine Hospital, were included. After the patients were positioned on the neurosurgical operating table, heart rate, systolic blood pressure, diastolic blood pressure, peripheral oxygen saturation, and entropy values were measured in all cases. Baseline values were recorded for patients who underwent ANI (Analgesia Nociception Index) monitoring. In both groups, entropy values were targeted to remain within the range of 40-60. In the ANI group, ANI values were maintained between 50-70. Patients were divided into two groups based on the intraoperative monitoring method applied: the ANI group (n=38) and the control group (n=37). All patients underwent entropy monitoring, while ANI monitoring was exclusively used in the ANI group for pain management. In the ANI group, remifentanil infusion adjustments were made to keep ANI values within the 50-70 range. This study aimed to compare perioperative opioid consumption, postoperative pain, and recovery from anesthesia in patients undergoing intracranial surgery who received general anesthesia and analgesia management guided by either entropy monitoring alone or a combination of entropy and ANI monitoring.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Analgesia | — | UNRESOLVED | — |
| Infratentorial Neoplasms | Infratentorial Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Intraoperative Monitoring | — | UNRESOLVED | — |
| Pain Monitoring | — | UNRESOLVED | — |
| Pain, Postoperative | — | UNRESOLVED | — |
| Pituitary Neoplasms | Pituitary Gland Neoplasm | ALIAS | 0.90 |
| Supratentorial Brain Tumor | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ANALGESIA NOCICEPTION INDEX MONITORING | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- ANI GROUP
- description
- ANI MONITORING
- interventionNames
- Device: ANALGESIA NOCICEPTION INDEX MONITORING
- label
- CONTROL GROUP
- description
- STANDARD MONITORING
Primary outcomes (1)
- measure
- INTRAOPERATIVE OPIOID USE
- timeFrame
- during the surgery/procedure
- description
- Lower dose opioid use during surgery is associated with more favorable outcomes in terms of postoperative pain and recovery scores.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * ASA I-II patients * Patients between the ages of 18-80 * patients undergoing intracranial surgery Exclusion Criteria: * major comorbid diseases, * patients using beta adrenergic blockers, clonidine, * patients with pacemakers or significant arrhythmias (e.g. atrial fibrillation), * patients using medications that affect sinus rhythm (atropine, ephedrine, glycopyrrolate), * patients with chronic pain and cerebrovascular diseases, * patients who will undergo planned postoperative ventilation, * patients with chronic pain due to opioid medications, and patients with opioid addiction
References
Publications (0)
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