Clinical trial · Observational
Gut Microbiome and Colorectal Cancer
Gut Microbiome Dyspiosis in Colorectal Cancer Egyptian Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer (CRC) is reported to be the third leading cause of cancer deaths worldwide, and its prevalence is steadily rising in developing countries. It can be considered a marker of socioeconomic development and a marker of significant changes in food habits and lifestyle. In Egypt, CRC represents the seventh most common cancer. It is the third most reported cancer in males and the fifth most common cancer in females. microbiome dysbiosis may be involved in the pathogensis and thus pose a therapeutic target
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| no intervention | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- contol group
- description
- 6 healthy participants
- interventionNames
- Other: no intervention
- label
- CRC group
- description
- 12 newly diagnosed CRC patients
- interventionNames
- Other: no intervention
Primary outcomes (2)
- measure
- The effect of food and lifestyle on microbiome
- timeFrame
- "through study completion, an average of 1 year"
- description
- correlation between food and lifestyle with microbiome profiles
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Age of 40 years to 80 years * Patients with a newly diagnosed CRC Exclusion Criteria: * Patients with previously known CRC * Pregnancy or Lactation * Abdominal surgery within/up to 6 months prior to sample collection * Antibiotics, corticosteroids, or probiotics up to three months prior to sample collection * History of other types of cancer * Subjects on a special diet * Diabetes, liver, or kidney diseases * CRC patients who used enema or underwent colonoscopy up to one week before sample collection.
References
Publications (1)
- BACKGROUNDBaas FS, Brusselaers N, Nagtegaal ID, Engstrand L, Boleij A. Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis. Cell Host Microbe. 2024 Aug 14;32(8):1235-1247. doi: 10.1016/j.chom.2024.07.008. PMID 39146796