Clinical trial · Interventional
Cryotherapy in Combination with Red Light PDT for Actinic Keratosis of Full Face
A Single Center, Observational Study to Evaluate the Effectiveness and Safety of Cryotherapy in Combination with 10% ALA Gel Red Light PDT in the Treatment of Actinic Keratosis on the Full Face.
NCT06745999CI-TRIAL-00084017unknownPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
40 patients randomized 1:1 to receive cryotherapy followed by 10% ALA gel Red light PDT vs. to 10% ALA gel Red Light PDT followed by cryotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Actinic Keratoses | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Ameluz 10% Topical Gel | Drug | 5-Aminolevulinic Acid | ALIAS |
| Cryotherapy | Procedure | — | UNRESOLVED |
| Red Light PDT | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- cryotherapy followed by 10% ALA gel Red light PDT
- interventionNames
- Drug: Ameluz 10% Topical Gel
- Device: Red Light PDT
- Procedure: Cryotherapy
- type
- EXPERIMENTAL
- label
- 10% ALA gel Red Light PDT followed by cryotherapy
- interventionNames
- Drug: Ameluz 10% Topical Gel
- Device: Red Light PDT
- Procedure: Cryotherapy
Primary outcomes (1)
- measure
- Percentage change in total lesions at Week 24
- timeFrame
- 24 Weeks
- description
- Percentage change From Baseline in Total Lesion Complete Response at Week 24
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Male or female adult ≥ 18 years of age; 2. 6-12 actinic keratosis grade I, II, and III on the full face. 3. Willing to avoid excessive sunlight or ultraviolet (UV) light exposure, including the use of tanning beds, to the face or scalp during study participation. 4. Females of childbearing potential (FCBP) must have a negative serum pregnancy test at Screening and negative urine pregnancy test at Baseline. FCBP who engage in activity in which conception is possible must use one of the approved contraceptive options: hormonal contraception; intrauterine device (IUD); tubal ligation; or partner's vasectomy; Male or female condom diaphragm with spermicide, cervical cap with spermicide, or contraceptive sponge with spermicide. 5. Able and willing to give written informed consent prior to performance of any study-related procedures Exclusion Criteria: 1. Presence of other skin conditions that may affect the study participant, investigator's ability to assess treatment, or intolerance to any ingredient in 10% ALA gel. 2. Treatment with 5-fluorouracil (5-FU), imiquimod, ingenol mebutate, diclofenac, photodynamic therapy, or other topicals and treatments for AK within the treatment area or within 2 cm of the treatment area, within 12 weeks of baseline. 3. Use of liquid nitrogen, excision, curettage, dermabrasion, chemical peel or laser resurfacing in the treatment area within 60 days. 4. Use of systemic retinoids (eg, isotretinoin, acitretin) within 6 months 5. Women of childbearing potential who are pregnant, intend to become pregnant, or are lactating. 6. Use of any investigational drug within 4 weeks prior to enrollment or within 5 pharmacokinetic/pharmacodynamic half-lives, if known (whichever is longer). 7. Any clinically significant (as determined by the Investigator) cardiac, endocrinologic, pulmonary, neurologic, psychiatric, hepatic, renal, hematologic, immunologic disease, or other major disease that is currently uncontrolled.
References
Publications (0)
Data not yet available
No reference posted for this study.