Clinical trial · Interventional
Evaluating the Impact of Quitting Using Executive Function Strategy Training (QUEST) on Smoking Cessation in Homeless Young Adult Smokers
QUEST (Quitting Using Executive Function Strategy Training) Research Protocol
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This clinical trial evaluates the impact of Quitting Using Executive Function Strategy Training (QUEST) on quitting smoking (cessation) in homeless young adult smokers with an acquired brain injury (ABI). Over 70% of youth and young adults experiencing homelessness (YYEH) smoke tobacco. More than half of YYEH who smoke have made at least one attempt to quit smoking but few use evidence-based methods to increase success. In addition, 9 out of 10 of these have an acquired brain injury which may have a negative impact on successful smoking cessation. QUEST may help homeless young adult smokers with an ABI quit smoking.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cigarette Smoking-Related Carcinoma | Cigarette Smoking-Related Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biospecimen Collection | Procedure | — | UNRESOLVED |
| Cognitive Assessment | Procedure | — | UNRESOLVED |
| Interview | Other | — | UNRESOLVED |
| Nicotine Replacement | Drug | — | UNRESOLVED |
| Smoking Cessation Intervention | Behavioral | — | UNRESOLVED |
| Survey Administration | Other | — | UNRESOLVED |
| Tobacco Cessation Counseling | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Prevention (QUEST)
- description
- Patients receive access to the Ohio Tobacco Quitline, receive nicotine patches, gum, or lozenges for up to 8 weeks. Patients also participate in tobacco cessation counseling sessions for 5 sessions over 8 weeks. Patients additionally undergo cognitive assessment and nasal swab collection on study.
- interventionNames
- Procedure: Biospecimen Collection
- Procedure: Cognitive Assessment
- Other: Interview
- Drug: Nicotine Replacement
- Behavioral: Smoking Cessation Intervention
- Other: Survey Administration
- Other: Tobacco Cessation Counseling
Primary outcomes (4)
- measure
- Rate of executive function difficulties
- timeFrame
- Up to 8 weeks
- description
- The number of times participants experience executive function difficulties with adhering to the Quit Line protocol will be recorded via survey questionnaires.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 24 Years
Show eligibility criteria text
Inclusion Criteria: * 18-24 years old * Utilizing STAR House ( a drop-in center for youth and young adults experiencing homelessness) services * Use of combustible tobacco product in the last week * Willing to quit smoking in the next 30 days * Acquired Brain Injury (ABI) (15 youth with and 15 without) * CHATS will be used to determine ABI. Ask "C", "H" and "A" of the CHATS tool. If yes to C OR H and yes to A, that will be considered positive for ABI * Have access to a phone * Willing to use phone for QuitLine (QL) services * Willing to enroll in Ohio Tobacco Quit Line * Willing to share Ohio Tobacco Quit Line portal data with researchers * Willing to provide biospecimens (exhaled air and nasal samples) * Conversational English skills
References
Publications (0)
Data not yet available