Clinical trial · Interventional
The Diagnostic Value of Bronchoscopic Needle-based Confocal Laser Endomicroscopy (nCLE) As a Real-time Detection Tool for Diagnosing Peripheral Lung Cancer: a Multi-centre Randomised Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this prospective, multi-centre, randomised controlled clinical study is to evaluate the diagnostic efficacy and safety of nCLE guided lung biopsy in patients with for peripheral lung nodules under the assistance of navigation bronchoscopy (NB) and radial endobronchial ultrasound (rEBUS), and assess whether the biopsy techniques, namely transbronchial crybiopsy (TBCB) and transbronchial forceps biopsy (TBFB), would influence the diagnostic efficacy and safety of nCLE guided biopsy. Participants will divided into nCLE-NB-rEBUS-forcep biopsy group, nCLE-NB-rEBUS-TBCB group, NB-rEBUS-forcep biopsy group, and NB-rEBUS-TBCB group at a 1:1:1:1 ratio by using central, computerized random sequence, and then undertake nCLE-NB-rEBUS-forcep biopsy, nCLE-NB-rEBUS-TBCB, NB-rEBUS-forcep biopsy, and NB-rEBUS-TBCB according to the group. Researchers will compare the diagnostic yield and incidence of adverse events of the four biopsy techniques.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer, Non-Small Cell | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
| Lung Cancer, Small Cell | Lung Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| NB-rEBUS-forcep biopsy | Procedure | — | UNRESOLVED |
| NB-rEBUS-TBCB | Procedure | — | UNRESOLVED |
| nCLE-NB-rEBUS-forcep biopsy | Procedure | — | UNRESOLVED |
| nCLE-NB-rEBUS-TBCB | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- nCLE-NB-rEBUS-forcep biopsy
- description
- The participants would undergo lung biopsy using forcep, under the guidance of bronchoscopic needle-based confocal laser endomicroscopy (nCLE) with the assistance of navigation bronchoscopy (NB) and radial endobronchial ultrasound (rEBUS)
- interventionNames
- Procedure: nCLE-NB-rEBUS-forcep biopsy
- type
- EXPERIMENTAL
- label
- nCLE-NB-rEBUS-TBCB
- description
- The participants would undergo transbronchial crybiopsy (TBCB) , under the guidance of bronchoscopic needle-based confocal laser endomicroscopy (nCLE) with the assistance of navigation bronchoscopy (NB) and radial endobronchial ultrasound (rEBUS)
- interventionNames
- Procedure: nCLE-NB-rEBUS-TBCB
- type
- ACTIVE_COMPARATOR
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * patients with peripheral lung nodules suspected of lung cancer based on CT scan (10mm≤size\<30mm); * patients requiring diagnostic bronchoscopy procedure to determine the benign or malignant nature of the lung nodule; * Patients who can understand the purpose of the trial, participate voluntarily and sign an informed consent form. Exclusion Criteria: * Inability or non-willingness to provide informed consent; * Endobronchial visible malignancy on bronchoscopic inspection; * Target lesion within reach of the linear EBUS scope; * Failure to comply with the study protocol; * Known allergy or risk factors for an allergic reaction to fluorescein; * Pregnancy or breast feeding; * Haemodynamic instability; * Refractory hypoxaemia; * Therapeutic anticoagulant use that cannot be withheld for an appropriate interval before the procedure; * Unable to tolerate general anaesthesia according to the anaesthesiologist; * Undergoing chemotherapy as several chemotherapies have fluorescent properties at the same wavelength (eg, doxorubicin).
References
Publications (0)
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