Clinical trial · Interventional
Efficacy of Botox Injection of the Masticatory Muscles in Head &Neck Cancer Patients with Trismus After Radiotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Trismus is a common side effect in head and neck cancer patients after radiation therapy. This project aims to explore the therapeutic effect of Botulinum toxin (Botox) injection to the masticatory muscles in the above-mentioned patients. In this project, Botulinum toxin will be injected into the masticatory muscles (medial pterygoid and masticatory muscles), combined with oral rehabilitation exercises, to reduce the patient's masticatory muscle tension and spasm. Patient's mouth opening range, quality of life, trismus condition and pain will be evaluated to understand its efficacy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| BOTOX | — | UNRESOLVED | — |
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Radiation Therapy Recipient | — | UNRESOLVED | — |
| Trismus | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Echo-guided Botox injection | Drug | — | UNRESOLVED |
| echo-guided normal saline injection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Botox injection
- interventionNames
- Drug: Echo-guided Botox injection
- type
- PLACEBO_COMPARATOR
- label
- Normal Saline Injection
- interventionNames
- Procedure: echo-guided normal saline injection
Primary outcomes (1)
- measure
- Maximal Incisal Opening
- timeFrame
- From enrollment to the end of treatment at 6 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Aged over 18 years old; 2. Head and neck cancer patients must have completed radiotherapy for at least 3 months; 3. Those whose mouth-opening distance is less than or equal to 3.5 cm (the functional cut-off point of trismus) and who have tightness or pain in the masticatory muscles; 4. Medical condition is stable; Exclusion Criteria: 1. Those who have undergone surgery on their masticatory muscles; 2. Patients with obvious muscle atrophy or complete fibrosis of masticatory muscles ; 3. Those with tumor recurrence at the time of admission; 4. Those whose vital signs are unstable due to acute illness.
References
Publications (0)
Data not yet available