Clinical trial · Interventional
A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer
A Scalable Cruciferous Vegetable Intervention to Reduce Bladder Cancer Recurrence and Progression
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 18, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260918-000001
Summary
Brief summary (as posted)
This phase II trial is being done to develop and test a healthy eating program to reduce cancer recurrence (cancer that has come back after a period of improvement) and/or progression (cancer that is growing, spreading, or getting worse) in patients with non-muscle invasive bladder cancer (NMIBC). Researchers want to better understand how incorporating more cruciferous vegetables in the diet may reduce the risk of cancer recurrence or progression in men and women who were diagnosed with early-stage bladder cancer and compare whether extending the program can further improve bladder cancer outcomes. POW-R Health is a behavioral dietary intervention designed to modestly increase cruciferous vegetable (cruciferae) intake in patients. Cruciferous vegetables, such as cabbage, kale and broccoli, arugula, contain phytochemicals known as isothiocyanates (ITCs). Dietary ITCs exert potent anticancer activities against bladder cancer and can be rapidly metabolized, delivered to the bladder, and concentrated in the urine. Participating in the healthy eating program may reduce bladder cancer recurrence or progression in NMIBC survivors.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-Muscle Invasive Bladder Carcinoma | Non-Muscle Invasive Bladder Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Recurrent Bladder Carcinoma | Bladder Carcinoma | CURATED_BROADER | 0.78 |
| Recurrent Non-Muscle Invasive Bladder Carcinoma | Non-Muscle Invasive Bladder Carcinoma | CURATED_BROADER | 0.78 |
| Stage 0a Bladder Cancer AJCC v8 | Malignant Bladder Neoplasm | CURATED_BROADER | 0.78 |
| Stage 1 Bladder Cancer AJCC v8 | Bladder Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Behavioral Dietary Intervention | Behavioral | — | UNRESOLVED |
| Telephone- Based Intervention | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Adaptation
- description
- CAB members participate in maintenance phase development discussion over an hour up to 3 times per week.
- interventionNames
- Behavioral: Behavioral Dietary Intervention
- type
- EXPERIMENTAL
- label
- Arm II - POW-R Health Only/Core + Maintenance
- description
- Patients receive study materials and phone calls during life of study
- interventionNames
- Behavioral: Telephone- Based Intervention
Primary outcomes (1)
- measure
- Urinary isothiocyanates (ITCs) levels
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria:
* English speaking
* Diagnosed with stage Tis, Ta, or T1 bladder cancer
* Age 18 years old or older (no upper limit)
* Resides in New York State
* Cancer not reported by a lab, nursing home, or death certificate/autopsy only
* Did not receive a partial or radical cystectomy
* Does not have other cancer diagnosis within 12 month of bladder cancer diagnosis except for cancers deemed low risk and unlikely to impact study participation (e.g., basal cell carcinoma, nor under active treatment for any other cancers
Exclusion Criteria:
* Participants who had chemotherapy or radiotherapy within 4 weeks (6 weeks for nitrosoureas or mitomycin C) prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier
* Adults unable to consent
* Adults unable to complete study measures in English
* Individuals who are not yet adults (infants, children, teenagers)
* Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Unwilling or unable to follow protocol requirements
* The following special populations ae excluded from this study:
* Cognitively impaired adults/adults with impaired decision-making capacity
* Individuals who are not yet adults (infants, children, teenagers)
* Pregnant women
* PrisonersReferences
Publications (0)
Data not yet available