Clinical trial · Interventional
Phase II Study of Golidocitinib and Benmelstobart in Patients with R/R ENKTL (JACKPOT50)
A Single-arm, Open-label, Phase II Study of Golidocitinib and Benmelstobart Combination Treatment in Patients with Relapsed or Refractory Extranodal Natural Killer/T Cell Lymphoma (ENKTL) (JACKPOT50)
NCT06733051CI-TRIAL-00085705JACKPOT50recruitingPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, single-arm, multicenter, phase II clinical trial to evaluate the efficacy and safety of golidocitinib and benmelstobart combination treatment in patients with relapsed or refractory extranodal natural killer/T cell lymphoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Natural Killer T-cell Lymphoma | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Benmelstobart | Drug | — | UNRESOLVED |
| Golidocitinib | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Golidocitinib and Benmelstobart Combination
- description
- Patients will receive golidocitinib in combination with benmelstobart every 3 weeks for up to 24 months, until disease progression, unaccpetable toxicities or other reasons lead to discontinuation.
- interventionNames
- Drug: Golidocitinib
- Drug: Benmelstobart
Primary outcomes (1)
- measure
- Objective response rate(ORR)
- timeFrame
- 2 years
- description
- The proportion of patients who achieve complete remission (CR) or partial remission (PR) as the best response.
Secondary outcomes (5)
- measure
- Complete Response(CR)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Subjects fully understand and voluntarily participate in this study and sign informed consent. 2. Pathologically confirmed extranodal natural killer/T cell lymphoma (ENKTL). 3. Age ≥18, no gender limitation. 4. Treatment failure to at least one line of asparaginase-based therapy. 5. Eastern Cooperative Oncology Group performance status of 0-2 6. Expected survival ≥ 3 months. 7. At least one measurable lesion that meets Lugano 2014 criteria. 8. Sufficient organ function. Exclusion Criteria: 1. Invasive NK-cell leukemia or NKTCL that has progressed to leukemia. 2. Accompanied by hemophagocytic lymphohistiocytosis. 3. NKTCL with central nervous system invasion. 4. Previously treated with JAK inhibitors. 5. The patients have contraindications to any drug in the combined treatment. 6. Patients with the infection of human immunodeficiency virus (HIV) and/or acquired immunodeficiency syndrome. 7. Inability to swallow tablets, presence of malabsorption syndrome, or any other gastrointestinal disease or dysfunction that may affect the absorption of the study drug. 8. Pregnant and lactating women and subjects of childbearing age who do not want to use contraception. 9. Mentally ill persons or persons unable to obtain informed consent. The investigators think that the patient is not suitable for the study.
References
Publications (0)
Data not yet available
No reference posted for this study.