Clinical trial · Interventional
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction
Oxytocin Versus Human Chorionic Gonadotropin as Trigger in Ovulation Induction Cycles: A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to learn if injection oxytocin can be used as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome. The main questions it aims to answer are: * Does injection oxytocin have similar ovulation rate as injection human chorionic gonadotropin (hCG) when used as trigger? * Does injection oxytocin have similar pregnancy rate as injection human chorionic gonadotropin (hCG) when used as trigger? Researchers will compare injection oxytocin to injection hCG to see if injection oxytocin is as effective as injection hCG as trigger in ovulation induction cycles in infertile women with polycystic ovary syndrome. Participants will * Take injection oxytocin or injection hCG as trigger over three subsequent ovulation induction cycles * Be checked for ovulation by follicular rupture in TVS after 36 hours or raised serum progesterone level on day 7 after trigger * Be checked for pregnancy by urine pregnancy test kit after missed period
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Ovulation Induction | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Human Chorionic Gonadotropin | Drug | — | UNRESOLVED |
| Oxytocin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Oxytocin
- description
- Participants will receive injection oxytocin 10 mg intramuscular as trigger for ovulation induction
- interventionNames
- Drug: Oxytocin
- type
- ACTIVE_COMPARATOR
- label
- Human Chorionic Gonadotropin
- description
- Participants will receive injection Human Chorionic Gonadotropin 5000 IU intramuscular as trigger for ovulation induction
- interventionNames
- Drug: Human Chorionic Gonadotropin
Primary outcomes (1)
- measure
- Number of participants having ovulation
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Infertile women with polycystic ovary syndrome * Age less than 40 years * Had ovulation induction with letrozole, with at least one mature follicle detected on folliculometry Exclusion Criteria: * Male factor abnormality * Bilateral tubal block * Any pelvic pathology like pelvic inflammatory diseases * Any uterine abnormality * Ovarian cysts * Any cardiovascular diseases or other systemic diseases * Hyperprolactinemia or thyroid dysfunction * Any drugs that affect the functions of hypothalamus, pituitary gland, and gonads * Any known hypersensitivity to oxytocin
References
Publications (2)
- BACKGROUNDMehrotra S, Singh U, Gupta HP, Tandon I, Saxena P. A prospective double blind study comparing the effects of oxytocin and human chorionic gonadotrophin as trigger for ovulation. J Obstet Gynaecol. 2014 Jan;34(1):13-6. doi: 10.3109/01443615.2013.822479. PMID 24359041
- BACKGROUNDGeorge K, Kamath MS, Nair R, Tharyan P. Ovulation triggers in anovulatory women undergoing ovulation induction. Cochrane Database Syst Rev. 2014 Jan 31;2014(1):CD006900. doi: 10.1002/14651858.CD006900.pub3. PMID 24482059