Clinical trial · Observational
A Comparison Study of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
Comparison of Persistence of UPadacitinib vs. TNF-inhibitoRs In a German Real-world SettING
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will compare the retention rates for UPA vs. TNFi treatment in adult participants with moderate to severe active RA per local label and according to local standard of care This is a mono-country, prospective, multi-center observational study in patients with moderate to severe active RA receiving UPA or TNFi therapy. Around 678 participants will be enrolled in approximately 80 sites in Germany. Study recruitment will last approximately 24 months, and the study participation time will be up to 24 months, for a total study duration of approximately 48 months.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Moderate to Severe Rheumatoid Arthritis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Upadacitinib
- description
- Participants will receive upadacitinib as prescribed by their physician according to local label.
- label
- Tumor Necrosis Factor Inhibitor-Treatment
- description
- Participants will receive a tumor necrosis factor inhibitor treatment as prescribed by their physician according to local label.
Primary outcomes (1)
- measure
- Retention Rate of UPA vs TNFi
- timeFrame
- Up to approximately 24 months
- description
- Time to the discontinuation of Upadacitinib. Time to the discontinuation of Tumor Necrosis Factor Inhibitor treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Current or Past participants with a confirmed diagnosis of moderate to severe active RA upon judgement of the treating physician. * Physician decision on participant treatment with Upadacitinib (UPA) or tumor necrosis factor inhibitor (TNFi) must have been reached prior to and independently of recruitment in the study * UPA or TNFi prescribed in accordance with the applicable approved label and local regulatory and reimbursement policies Exclusion Criteria: * Participation in a clinical trial with an investigational drug (within a minimum of 30 days or 5 half-lives of the investigational drug \[whichever is longer\] prior to baseline) * Prior treatment with Upadacitinib * Prior treatment with the same tumor necrosis factor inhibitor as the one prescribed for this study
References
Publications (0)
Data not yet available