Clinical trial · Observational
Differential Study of Invasive Pituitary Adenomas in the Sellar and Cavernous Sinus Regions
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study involves collecting paired tumor samples from intrasellar and cavernous sinus regions of 20 invasive pituitary tumor patients, preserving them at -80°C for quality multi-omics analysis. Proteomics and transcriptomics are employed to identify molecular differences, while imaging data (MRI/CT) assesses tumor morphology and invasion. In vitro experiments and mechanistic studies validate key findings, exploring how regional molecular differences affect tumor behavior. Data integration combines multi-omics and imaging features to uncover biomarkers and pathways associated with invasiveness and regional specificity, with statistical analysis ensuring significance and reliability.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pituitary Tumor | Pituitary Gland Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- pituitary tumors in cavernous sinus group
- description
- The 20 pituitary tumor samples in this group were obtained from the cavernous sinus region removed during surgery and were paired with pituitary tumors in the intralellar region
- interventionNames
- Other: surgery
- label
- pituitary tumors in sellar group
- description
- The 20 pituitary tumors in this group were obtained from intrasellar samples removed during surgery and were paired with pituitary tumors in the cavernous sinus region
- interventionNames
- Other: surgery
Primary outcomes (1)
- measure
- Differences in pathological features of tumors
- timeFrame
- 2025/12/01-2026/12/01
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Invasive pituitary tumors involving the cavernous sinus 2. Retrospective inclusion of patients who have signed informed consent forms for the donation of biological samples and health-related information 3. Age range: 18-80 years 4. Subjects are willing to participate in this study Exclusion Criteria: 1. Non-invasive pituitary tumors 2. Pregnant or breastfeeding 3. Other conditions deemed unsuitable for participation in this clinical trial as assessed by the physician
References
Publications (0)
Data not yet available