Clinical trial · Observational
Functional and Morphological Characterization of Multiple Osteochondromas Disorder
Misure di funzionalità e deformità Dell'Apparato Muscolo-scheletrico Come "Biomarkers" Per il Trattamento di Malattie Ortopediche/Accessible Measurements of Mobility and Deformity as Biomarkers for Orthopaedic Treatments
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The main purpose of the study is the characterization of functional and morphological alterations due to multiple osteochondromas in a pediatric and adult population through the identification of relevant anthropometric and functional parameters. The morphological and functional data, supplemented with clinical and postural data, will allow the characterization of the disease with an holistic approach that can provide important information to properly assess timing for surgical treatments and to improve the quality of life of these patients. Another goal of the study is the assessment and the validation of novel instruments and tools to measure joint mobility and bone deformity. These instruments should be easy-to-use and designed to be operated locally by the patients themselves and/or in small clinics by operators with little training and no specific high-technical knowledge. The final goal of the study is the assessment of the quality of life and balance perception of patients, using questionnaires.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hereditary Multiple Osteochondromas | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Multiple osteochondromas patients
- description
- The cohort is composed of patients suffering from hereditary multiple osteochondromas (HMO) and it contains 30 subjects: 15 minors (6-17 years) and 15 adults (18-40 years). The inclusion criteria of HMO cohort are: clinical and/or molecular diagnosis of Multiple Osteochondromas; male and female subjects; collection of appropriate informed consent; ability to walk a linear path without aids; presence of OM localized at lower limbs; ability to undergo all procedures required by the protocol. Are excluded from the cohort subjects with body mass index (BMI) equal to or greater than 30.
- label
- Healthy subjects
- description
- Healthy subjects are control population, equivalent in gender and age to the investigated population. The cohort is composed of 30 subjects: 15 minors (6-17 years) and 15 adults (18-40 years).The inclusion criteria of healthy cohort are: absence of neuro-muskuloskeletal or other limb-limiting conditions in the lower limbs; male and female subjects; collection of appropriate informed consent; ability to undergo all procedures required by the protocol. Are excluded from the cohort subjects with body mass index (BMI) equal to or greater than 30.
Primary outcomes (2)
- measure
- Functional motor assessment
- timeFrame
- From subjects enrollment to the end of the assessment. Patients repeat these activities after 12 months from the first evaluation, while healthy subjects carry out the same activities of unhealthy population only once.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: For multiple osteochondromas cohort inclusion criteria are: * clinical and/or molecular diagnosis of Multiple Osteochondromas; * male and female subjects; * age minors: 6-17 years at enrollment and adult age: 18-40 years at enrollment; * collection of appropriate informed consent; * ability to walk a linear path without aids; * presence of multiple osteochondromas localized at lower limbs; * ability to undergo all procedures required by the protocol. For healthy cohort inclusion criteria are: * absence of neuro-muskuloskeletal or other limb-limiting conditions in the lower limbs; * male and female subjects; * age minors: 6-17 years at enrollment and adult age: 18-40 years at enrollment; * collection of appropriate informed consent; * ability to undergo all procedures required by the protocol. Exclusion Criteria: * Persons who do not fit the inclusion criteria; * Any reason which, in the opinion of the investigator, would result in the inability of the participant to comply with the protocol. * BMI equal to or greater than 30.
References
Publications (0)
Data not yet available