Clinical trial · Observational
High Resolution Anuscopy Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The majority of anal squamous cell carcinomas (SCC) stem from infection with high-risk human papillomavirus (HPV). Anal SCC is rare among the general population but affects several populations disproportionately. High-risk groups are screened through anal swabs for anal cytology and detection of high risk human papillomavirus (HR HPV). HRA referral is recommended for individuals with abnormal cytology. HRA represents the only method to identify precancerous lesions of the anal canal, with only few specialists knowledgeable about it. At UZ Brussel, the investigators collected a wealth of data about HPV infection and its association with anal pathology. By establishing a comprehensive study, the investigators can delve into this data with specific research questions, conducting valuable research to provide answers to pressing clinical questions and contribute to advancements in medical understanding and treatment.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anal Squamous Cell Carcinoma | Anal Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Human Papilloma Virus | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| HRA | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (6)
- measure
- comparison of the prevalence of precancerous lesions in men who have sex with men using PrEP or are HIV positive Men
- timeFrame
- Through study completion, on average 5 years
- measure
- Exploration of associations between abnormal histology and patient characteristics
- timeFrame
- Through study completion, on average 5 years
- measure
- comparison of the prevalence of precancerous lesions in different groups
- timeFrame
- Through study completion, on average 5 years
- measure
- to delineate unique features associated with HSIL in each risk group by linking patterns or characteristics
- timeFrame
- Through study completion, on average 5 years
- description
- such as verrucous aspects, coarse punctuation, mosaic patterns, flat morphology, and fragility
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All patients who have undergone HRA and all future patients referred for HRA in UZ Brussel * 18 years or older * Understands and able to speak and write in French, Dutch or English Exclusion Criteria: * None
References
Publications (0)
Data not yet available