TGRX-678 Phase I Oral Pharmacokinetic Study

Inclusion Criteria:

* Healthy participants, male or female
* Age between 18 and 45 (both inclusive)
* Body Weight: male ≥ 50 kg, female ≥ 45 kg; Body Mass Index (BMI) between 19.0 and 26.0 kg/m\^2 (both inclusive)
* Signing informed concent at own will
* Able to communicate with researcher and able to complete study per protocol instruction

Exclusion Criteria:

* Clinically significant abnormal results in lab test, physical exam or 12-lead electrocardiogram (ECG) test
* Positive results for Hepatitis B, Hepatitis C, HIV or Syphilis
* QT interval elongation as indicated by 12-lead ECG test during screening period
* Use of any medication that could impact CYP3A4 enzyme activities within 30 days prior to Screening period
* Use of any medication within 14 days of first dose of the investigational drug
* Vaccinated within 30 days of first dose of the investigational drug, or planning to be vaccinated during study
* History of instrumental cardiovascular diseases
* Received major surgery within 6 months prior to Screening, or with surgical wounds not completely healed
* History of any severe disease or conditions that could affect study results per investigator's discretion
* History of allergic conditions or is allergic to components of the investigational drug
* Having conditions that could affect drug absorption or difficulties to swallow
* History of smoking of \>5 cigarettes per day within 3 months prior to screening, or cannot stop tabacco using during study
* History of alcohol abuse, or alcohol consumption of \>14 unit alcohol within 3 months prior to screening
* History of substance use, or tested positive for drug test during screening
* History of specific food (i.e., grapefruit, mango) consumption, or/and large tea/coffee/caffeinated drink/grapefruit product intake of \> 8 cups per day, within 2 weeks prior to first dose
* Having special dietary requirement and cannot comply with food requirement of the study
* Pregnant or breastfeeding female, or tested positive in pregnancy test
* History of unprotected sexual activities within 1 month prior to screening
* Having plans for pregnancy during the study and within 6 months after study completion; or not agreeing to take strict contraceptive measures during study and within 6 months after study completion
* History of blood loss/ blood donation of ≥ 400 mL within 3 months prior to screening, or planning to donate blood within 1 month after study completion
* Any reasons that is deemed unsuitable for study participation as determined by investigator