Clinical trial · Observational
EOCRCPred: an AI Model to Predict Survival in EOCRC Patients After Surgery
EOCRCPred: an AI Model for Predicting Overall Survival in Early-Onset Stage I-III Colorectal Cancer Patients Post-Radical Resection-A SEER Database and Dual-Center Chinese Medical Institutions Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to develop a predictive model for overall survival in patients under the age of 50 who have undergone surgery for early-onset colorectal cancer (EOCRC). The main question it aims to answer is: Can machine learning models accurately predict the long-term survival of EOCRC patients after surgical treatment? Participants who have already undergone surgery for EOCRC as part of their regular medical care will have their clinical data analyzed, with survival outcomes tracked through follow-up assessments. An online survival calculator will also be developed to aid clinicians and patients in predicting personalized survival outcomes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (1)
- label
- external validation cohort
- description
- The external validation cohort was composed of primary EOCRC patients who underwent radical resection at Putuo Hospital and Yueyang Hospital, both affiliated with Shanghai University of Traditional Chinese Medicine. The cohort includes patients diagnosed between January 2014 and June 2024. Inclusion criteria: Patients with pathologically confirmed primary EOCRC, aged under 50 years, and who received radical surgery (stages I-III according to the AJCC 7th edition). Exclusion criteria: Patients with multiple primary cancers, survival time under 1 month, or missing critical data.
Primary outcomes (1)
- measure
- Assessment of Clinical Characteristics and Survival Status of Subjects Using the CRF Scale
- timeFrame
- 2024.11
- description
- Age, Gender, Race, Primary Site, Tumor Diameter, Differentiation Degree, Histology, TNM Stage, CEA, Surgery Type, Number of Resected Lymph Nodes, Tumor Deposits, Neural Invasion, Radiation Sequence, Chemotherapy Sequence, Systemic Therapy Sequence, Marital Status, Household Income, Survival Status, Postoperative Survival Time.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 49 Years
Show eligibility criteria text
Inclusion Criteria: * Primary EOCRC confirmed by pathological histological examination (ICD-10 codes: C18.0, C18.2-18.9, C19.9, C20.9) * Radical surgery performed (Specific Surgery Codes 30-70, including partial/subtotal colectomy, hemicolectomy, right/left colectomy, and total colectomy, as well as partial or total removal of other organs and regional lymph nodes) * Stage I-III disease according to the 7th AJCC-TNM system Exclusion Criteria: * Patients with multiple primary cancers or other malignancies * Survival time of less than 1 month, or absence of postoperative follow-up information * Incomplete critical clinical feature information
References
Publications (0)
Data not yet available