Clinical trial · Observational
Endoscopy and Primary Sclerosing Cholangitis
Endoscopic Therapy in Patients With Primary Sclerosing Cholangitis: 30 Years of Experience
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Primary Sclerosing Cholangitis (PSC) is a chronic, cholestatic, immune-mediated liver disease characterized by segmental inflammation, fibrosis and destruction of the intra and / or extrahepatic biliary tree. Patients suffering from PSC can develop biliary strictures and symptoms (jaundice, itching, cholangitis) requiring endoscopic therapy by Endoscopic Retrograde Cholangiopancreatography (ERCP). ERCP can play an important role in symptoms control, cholangiocarcinoma diagnosis. PSC can lead to liver failure and subsequent need for liver transplantation, ERCP can therefore delay the time for liver transplantation. With this work the investigators want to report our thirty years of experience in the endoscopic treatment of PSC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Primary Sclerosing Cholangitis (PSC) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Endoscopic Retrogradade CholangioPancreatography (ERCP) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Patients undergoing Endoscopic Retrograde CholangioPancreatyopgraphy for PSC
- description
- Patients undergoing Endoscopic Retrograde CholangioPancreatyopgraphy (ERCP) to dilate dominant biliary strictures related to Primary Sclerosing cholangitis (PSC)
- interventionNames
- Procedure: Endoscopic Retrogradade CholangioPancreatography (ERCP)
Primary outcomes (1)
- measure
- Effectiveness of long-term endoscopic treatment
- timeFrame
- From Enrollment to the last follow-up, 3 years
- description
- PSC can lead to liver failure and need for liver transplantation. Endoscopic therapy can have a positive impact to delay the need for liver transplantation
Secondary outcomes (3)
- measure
- Need for Endoscopic retreatment
- timeFrame
- From Enrollment to the last follow-up, 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed with PSC and biliary tract stenosis with indication for endoscopic treatment. Exclusion Criteria: * Patients with unclear diagnosis of PSC. * Patients ineligible for endoscopic therapy.
References
Publications (0)
Data not yet available