Clinical trial · Observational
Effect of Donor Chose on the Outcomes of GVHD Prophylaxis Underwent the Combined Treatment of ATG/PTCy for Haplo-HSCT
The Effect of the Parous Female and Young Male Donor on the Outcomes of GVHD Prophylaxis Underwent the Combined Treatment of ATG and PTCy for Haplo-HSCT: a Prospective, Multi-center, Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a prospective, multicenter, cohort study. The high-risk, relapse and refractory AML patients were enrolled in this study. And the goal of this study is to study the effect of the parous female donor and young male donor on the outcomes of graft-versus-host disease (GVHD) prophylaxis underwent the combination of ATG and PTCy for haploidentical peripheral blood stem cell transplantation
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| High-Risk Acute Myeloid Leukemia | — | UNRESOLVED | — |
| Relapse And/or Refractory AML | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| donor selection | Other | — | UNRESOLVED |
| None-placebo | Other | — | UNRESOLVED |
| non-intervention study | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- RFS
- timeFrame
- one year
- description
- 1-year RFS after transplantation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: 1\. Acute myeloid leukemia was diagnosed according to the 2016ELN criteria with any of the following: 1. ELN prognostic stratification high-risk group (see Appendix for criteria) 2. Non-remission (NR) AML: including primary refractory AML and NR patients after relapse. 2\. Patients must have a suitable hematopoietic stem-cell donor. 1. Patients had to have a qualified haploidentical young male (≤30 years old) or female with a history of pregnancy; 2. Related donors had to be related donors matched 5/10-7/10 for HLA-A, -B, -C, -DQB1 and -DRB1 3. All the enrolled patients received a unified GVHD prevention regimen based on ATG and PTCy Exclusion Criteria: 1. Intermediate-low risk AML patients (ELN criteria); 2. Patients with extramedullary active lesions at the time of transplantation; 3. Haploidentical collateral donors; 4. Patients who refused allogeneic hematopoietic stem cell transplantation;
References
Publications (0)
Data not yet available