Clinical trial · Observational
EVALUATION OF POSTOPERATIVE NEUROCOGNITIVE IMPAIRMENT
THE EFFECT OF PEROPERATIVE TOTAL INTRAVENOUS ANESTHESIA AND INHALER ANESTHESIA ON POSTOPERATIVE NEUROCGNITIVE DISORDER IN BREAST CANCER SURGERY
NCT06685770CI-TRIAL-00082533active not recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In this prospective study, the effects of different anesthesia methods (total intravenous anesthesia and inhaled anesthesia) on neurocognitive function will be examined in patients undergoing breast-conserving surgery without axillary lymph node dissection. Mini-Mental State Examination and Mini-Cog tests will be administered at specific intervals pre and postoperatively. Anesthesia management will follow standard protocols, and the researcher will not intervent in these processes. The relationship between the type of anesthesia and neurocognitive outcomes will be evaluated based on the collected data.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Surgery | — | UNRESOLVED | — |
| General Anesthesia | — | UNRESOLVED | — |
| Neurocognitive Disorder | — | UNRESOLVED | — |
| Sevoflurane Anaesthesia | — | UNRESOLVED | — |
| Total Intravenous Anesthesia | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mini-cog test | Other | — | UNRESOLVED |
| Mini mental state assessment test | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- total intravenous anesthesia groups
- description
- In this study, neurological evaluation tests will be performed before and after surgery for patients who will undergo surgery for breast cancer. All patients will be followed during the perioperative period according to the standards specified in the American Society of Anesthesia guideline. Neurological evaluations will be performed at the 24th hour before surgery, on the day of surgery, and on the 1st, 3rd and 5th days after surgery. Those who underwent total intravenous anesthesia after peroperative anesthesia management will constitute this group. The total amounts of propofol and remifentanil consumed in this group will be recorded.
- interventionNames
- Other: Mini mental state assessment test
- Other: Mini-cog test
- label
- inhaled anesthesia groups
- description
- In this study, neurological evaluation tests will be performed before and after surgery for patients who will undergo surgery for breast cancer. All patients will be followed during the perioperative period according to the standards specified in the American Society of Anesthesia guideline. Neurological evaluations will be performed at the 24th hour before surgery, on the day of surgery, and on the 1st, 3rd and 5th days after surgery. Those who received inhaler anesthesia after peroperative anesthesia management will constitute this group. In this group, Minimal alveolar concentration levels of sevoflurane and total amounts of remifentanil will be recorded.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients with early stage breast cancer who will undergo breast-conserving surgery Exclusion Criteria: * Patients receiving neoadjuvant radiotherapy and chemotherapy * Patients who will undergo axillary lymph dissection and total mastectomy * Asa 4-5 patients * Patients without voluntary consent * Patients with previous surgery or vertebrobasilar insufficiency * Patients with Carotis stenosis * Patients with a visual analog scale above 4 in the postoperative recovery unit * Patients in whom cerebral oxygenation decreased by 15% from the beginning in cerebral oximetry monitoring during the perioperative period * Patients with bleeding that disrupts hemodynamics during follow-up and bleeding greater than 20% of body volume * Patients with postoperative intensive care unit follow-up * Patients with a decrease of more than 20% from the baseline systolic value (based on ward monitoring) during follow-up * Patients with intraoperative ventilation failure, patients with hypercarbia, hypocarbia * Patients whose Patient State Index value falls below 25, which is sufficient for the depth of anesthesia, during anesthesia induction or maintenance. * Patients with known neurological, psychiatric, unstable cardiovascular, renal or hepatic system disease * Patients with Uncontrolled Hypertension * Patients with greater than 1st degree heart block * Patients allergic to α2 adrenergic receptor agonist * Patients who cannot speak and do not know Turkish * Alcohol and substance addicted patients * Patients who have used opioids in the last 24 hours * Patients who developed sepsis during postoperative follow-up * Patients with a history of recurrent surgery
References
Publications (2)
- BACKGROUNDJo YY, Kim JY, Lee JY, Choi CH, Chang YJ, Kwak HJ. The effect of intraoperative dexmedetomidine on acute kidney injury after pediatric congenital heart surgery: A prospective randomized trial. Medicine (Baltimore). 2017 Jul;96(28):e7480. doi: 10.1097/MD.0000000000007480. PMID 28700489
- BACKGROUNDBocskai T, Kovacs M, Szakacs Z, Gede N, Hegyi P, Varga G, Pap I, Toth I, Revesz P, Szanyi I, Nemeth A, Gerlinger I, Karadi K, Lujber L. Is the bispectral index monitoring protective against postoperative cognitive decline? A systematic review with meta-analysis. PLoS One. 2020 Feb 13;15(2):e0229018. doi: 10.1371/journal.pone.0229018. eCollection 2020. PMID 32053678