Clinical trial · Interventional
Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer Adult | Malignant Liver Neoplasm | CURATED_EXACT | 0.85 |
| Liver Regeneration | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| carbon monoxide measurement via smokerlyzer | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- all participants
- description
- all participants will provide breath samples to detect carbon monoxide levels
- interventionNames
- Other: carbon monoxide measurement via smokerlyzer
Primary outcomes (1)
- measure
- correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
- timeFrame
- measurements will be taken pre, then 4 hours and 24 hours post resection
- description
- patients will be asked to donate exhaled breath into a smokerlyzer device
Secondary outcomes (3)
- measure
- level of carbon monoxide in exhaled air of patients
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient plans to have partial liver resection for primary liver pathology or metastatic disease * Patient is able to comprehend and willing to sign the written consent form Exclusion Criteria: * Patients \< 18 years * Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
References
Publications (0)
Data not yet available