Clinical trial · Interventional
Pralatrexate Combined With Chidamide Bridging Allogeneic HSCT for Refractory/Relapsed Peripheral T-cell Lymphoma
Pralatrexate Combined With Chidamide Bridging Allogeneic Hematopoietic Stem Cell Transplantation for Refractory/Relapsed Peripheral T-cell Lymphoma
NCT06671717CI-TRIAL-00082285not yet recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a multicenter, prospective study of Pralatrexate combined with Chidamide bridging Allogeneic Hematopoietic Stem Cell Transplantation for Refractory/Relapsed Peripheral T-cell Lymphoma
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Refractory Peripheral T-Cell Lymphoma | Peripheral T-Cell Lymphoma, Not Otherwise Specified | CURATED_BROADER | 0.78 |
| Relapsed Peripheral T-Cell Lymphoma | Peripheral T-Cell Lymphoma, Not Otherwise Specified | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Pralatrexate combined with Chidamide bridging Allogeneic Hematopoietic Stem Cell Transplantation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Pralatrexate combined with Chidamide bridging allo-HSCT for Relapse/Refractory PTCL patients
- description
- Pralatrexate combined with Chidamide bridging allo-HSCT for Relapse/Refractory PTCL patients
- interventionNames
- Other: Pralatrexate combined with Chidamide bridging Allogeneic Hematopoietic Stem Cell Transplantation
Primary outcomes (1)
- measure
- Progression-free survival (PFS) at 1 year after transplantation
- timeFrame
- Participants will be followed for an expected average of 1 years after transplantation
- description
- The time from the end of transplantation to progression of disease or death at 1year
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Patients fully understand the study, voluntarily participate in and sign on the informed consent; * Diagnosed by histopathology Peripheral T-cell lymphoma; * ECOG PS score 0 or 1; * Relapsed or Refractory Peripheral T Cell Lymphoma; * According to the 2014 version of the Lugano criteria for lymphoma, there must be at least one CT/MRI measurable lesion (measurable lymph node diameter\>1.5cm; measurable extranodal lesion diameter\>1.0cm); * Provided a written pathological/histological diagnosis report during the screening period and agreed to provide tumor tissue sections or tumor/lymph node tissue specimens for testing at the central laboratory; * Expected survival at least 12 weeks; * Agreed to receive treatment with Pralatrexate Exclusion Criteria: * NK/T-cell lymphoma; * Achieving CR or PR after induction chemotherapies without relapse; * Dysfunction of vital organs; * Serious history of autoimmune diseases and immunodeficiency, including: positive for human immunodeficiency virus (HIV) antibodies; Or other acquired or congenital immunodeficiency diseases; Or have a history of organ transplantation; * Unwilling to accept allogeneic hematopoietic stem cell transplantation; * Undergoing other clinical studies within a month; * Without donor for transplantation; * Allergies to similar drugs and excipients of the research drug
References
Publications (0)
Data not yet available
No reference posted for this study.