Clinical trial · Observational
Nomogram for Predicting Difficult Transoral and Submental Thyroidectomy
NCT06671184CI-TRIAL-00110721recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
No prior studies have stratified the difficulty of transoral and submental thyroidectomy (TOaST). The investigators aimed to investigate preoperative factors as indicators of difficult TOaSTs and to develop a predictive model accordingly.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Differentiated Thyroid Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Observations on clinicopathological factors influencing the difficulty of surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Difficult transoral and submental thyroidectomy
- description
- (1) operative time more than 75% of the overall study cases (2) severe intraoperative vascular or recurrent laryngeal nerve injury
- interventionNames
- Other: Observations on clinicopathological factors influencing the difficulty of surgery
- label
- Normal transoral and submental thyroidectomy
- description
- the remaining of the entire study cases excluding the difficult cases
- interventionNames
- Other: Observations on clinicopathological factors influencing the difficulty of surgery
Primary outcomes (4)
- measure
- Number of participants with recurrent laryngeal nerve injury
- timeFrame
- through study completion, an average of 1 year
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of differentiated thyroid cancer with a maximum diameter not exceeding 4 cm * Absence of suspicious lateral lymph nodes or distant metastases * Participants with high cosmetic expectations * Participants who underwent total thyroidectomy and central lymph node dissection. Exclusion Criteria: * Participants with fusion or fixation of lymph nodes in the neck * Participants with history of neck surgery or radiation * Participants with vocal fold fixation by preoperative fibrolaryngoscope * Participants with preoperative examination suggestive of extrathyroidal invasion * Participants with a significantly restricted neck
References
Publications (2)
- RESULTZhan L, Xuan M, Ding H, Liang J, Zhao Q, Chen L, Yang Z, Cheng X, Kuang J, Yan J, Cai W, Qiu W. Learning curve of trans-areola single-site endoscopic thyroidectomy in a high-volume center: A CUSUM-based assessment. Cancer Med. 2023 Aug;12(16):16846-16858. doi: 10.1002/cam4.6307. Epub 2023 Jul 3. PMID 37395126
- RESULTLiang J, Zhan L, Xuan M, Zhao Q, Chen L, Yan J, Kuang J, Tan J, Qiu W. Thyroidectomy for thyroid cancer via transareola single-site endoscopic approach: results of a case-match study with large-scale population. Surg Endosc. 2022 Feb;36(2):1394-1406. doi: 10.1007/s00464-021-08424-y. Epub 2021 Mar 29. PMID 33782758