Clinical trial · Interventional
Suturing Techniques for Vesico-urethral Anastomosis
A Pragmatic Randomized Controlled Trial Comparing the Effects of Suturing Techniques for Vesico-urethral Anastomosis on One-year Voiding Function After Radical Prostatectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Radical prostatectomy (RP) is the most common curative treatment for prostate cancer (PCa).Vesicourethral anastomosis (VUA) is a crucial step and either a conventional interrupted (IS) or a running (RS) suture is employed during radical prostatectomy (RP). Certainly, both RS and IS have advantages and limitations. The metanalysis revealed that potential advantages for RS compared to IS, especially for short-term outcomes such as catheterization time, extravasation rate, and anastomotic suture time. There were no significant differences for long-term outcomes (continence, incidence of vesicourethral anastomotic stenosis). Generally, the exciting evidence suggests that CS should be preferred over IS. However, this should be followed only if it is technically feasible and appropriate regarding the surgical approach. Both techniques seem to be safe and appropriate for the VUA, and the technique should be chosen based on individual experience and preference. The investigators hypothesized that RS and IS may have different effects on voiding function and flow rate, even if they do not cause an anastomotic stenosis requiring intervention. Furthermore, there is no existing literature that compares RS and IS in terms of voiding function.This article focuses on one year uroflowmetric voiding parameters, urinary function (UF), and UF related bother function, urinary continence recovery as well as other secondary outcomes, including surgical parameters, perioperative morbidity and oncological outcomes.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| interrupted suture for vesico-urethral anastomosis in open radical prostatectomy | Procedure | — | UNRESOLVED |
| Running suture for vesico-urethral anastomosis in open radical prostatectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Running suture (RS)
- description
- Running suture technique for vesico-urethral anastomosis in open radical prostatectomy
- interventionNames
- Procedure: Running suture for vesico-urethral anastomosis in open radical prostatectomy
- type
- ACTIVE_COMPARATOR
- label
- Interrupted suture (IS)
- description
- Interrupted suture technique for vesico-urethral anastomosis in open radical prostatectomy
- interventionNames
- Procedure: interrupted suture for vesico-urethral anastomosis in open radical prostatectomy
Primary outcomes (4)
- measure
- Maximum flow rate (MFR)
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- Male
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of clinically localised (pT1-pT2) prostate cancer * must select the open radical prostatectomy procedure as a treatment option. Exclusion Criteria: * History of acute urinary retention * History of urethral stricture
References
Publications (0)
Data not yet available