Clinical trial · Observational
Investıgatıon of Temporomandıbular Dysfunctıon in Patıents Wıth Breast Cancer-Related Lymphedema
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is the first study to examine temporomandibular joint dysfunction (TMD) in patients with breast cancer. The aim of the study was to investigate the relationship between lymphedema (LÖ) and TMD in patients with breast cancer. Socio-demographic characteristics of 38 individuals included in the study were recorded. Patients were divided into stage 0, 1 and 2 groups according to their LÖ stage and mild, moderate and advanced groups according to their TMD levels. In the evaluation of severity of lymphedema, Symptoms and Signs of TMD, pain threshold and tolerance assessment and normal range of motion, anxiety and depression, posture analysis environmental measurement, Craniomandibular Dysfunction Index for Clinical, Visual Analogue Scale (VAS) and algometer , goniometer and inclinometer, Turkish version of the Hospital Anxiety and Depression Scale (HAD) ,photogrammetric assessment method and inclinometer were used
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Lymphedema | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| only assesment | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- mild TMD
- interventionNames
- Other: only assesment
- label
- moderate TMD
- interventionNames
- Other: only assesment
- label
- advanced TMD
- interventionNames
- Other: only assesment
Primary outcomes (2)
- measure
- temporomandibular dysfunction
- timeFrame
- through study completion, an average of 1 year
- description
- The Clinical Craniomandibular Dysfunction Index (CDI) was used. CDI consists of five components including limited mandibular normal joint motion (RMJ), pain during mandibular RMJ, pain during TMJ palpation, pain during palpation of masticatory muscles and pain during mandibular function. 3 points can be given for each component as 0, 1 or 5 points and individuals are graded as no TMD (0 points), mild TMD (1-4 points), moderate TMD (5-9 points) and severe TMD (10-25 points) according to the scores received.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Female patients aged 18-75 years who were treated for unilateral breast cancer and developed breast cancer-related LE were included in the study Exclusion Criteria: * Patients with general joint diseases affecting the head and neck region that may cause TMD (e.g. rheumatoid arthritis), * jaw fracture, * trauma or orthognathic surgery history, * cervical disc herniation, * congenital disease, * facial paralysis, * patients who have been treated for TMD for the last 3 months and patients who use antidepressant drugs were excluded.
References
Publications (1)
- DERIVEDAkbulut Bayrak A, Tekbudak MY, Gultekin S, Keser I. Investigation of temporomandibular dysfunction in patients with breast cancer-related lymphedema. Support Care Cancer. 2025 May 7;33(6):455. doi: 10.1007/s00520-025-09500-y. PMID 40332621