Clinical trial · Observational
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy
Frequency of Periodontal Disease in Head and Neck Cancer Patients After Radiation Therapy: A Cross Sectional Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This prospective cross-sectional study evaluates the frequency and risk factors of periodontal disease in head and neck cancer patients who have undergone radiotherapy. 189 patients from three radiation centers in Cairo Governorate, Egypt will be included in the study. Periodontal status will be assessed according to the 2017 classification of periodontal diseases. Data will be collected through interviews, clinical examinations, and medical records. Potential risk factors, including tumor characteristics, treatment modalities, and oral health behaviors, will be analyzed. The findings aim to provide insights into the oral health challenges faced by these patients and inform better clinical management strategies.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Periodontal Diseases | — | UNRESOLVED | — |
| Periodontitis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (6)
- measure
- Clinical Attachment Loss (CAL)
- timeFrame
- Measured once during the study.
- description
- The distance from the cementoenamel junction (CEJ) to the bottom of the periodontal pocket. It indicates the amount of attachment loss due to periodontal disease. Measured with a periodontal probe at six sites per tooth.
- measure
- Probing Depth (PD)
- timeFrame
- Measured once during the study.
- description
- The distance from the gingival margin to the bottom of the periodontal pocket. Measured with a periodontal probe at six sites per tooth.
- measure
- Bleeding on Probing (BOP)
- timeFrame
- Assessed once during the study.
- description
- Presence or absence of bleeding from the gingival sulcus 10 seconds after probing with a standardized force. Assessed at six sites per tooth.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Over 18 years of age Any gender At least six remaining teeth Undergoing head and neck radiotherapy with or without chemotherapy for 6-7 weeks Head and neck malignancy including squamous cell carcinoma of the tongue, buccal mucosa, hard palate, soft palate, and base of tongue. Both mandible and maxilla included in the radiation field Exclusion Criteria: * Major surgical intervention (major hard tissue resection) Psychiatric disorders Distant metastatic disease Bone-related disorders Active untreated infection Palliative care Pregnancy Smokers
References
Publications (2)
- RESULT1. Petersen PE: Oral cancer prevention and control--the approach of the World Health Organization. Oral Oncol 2009, 45(4-5):454-460 10.1016/j.oraloncology.2008.05.023. 2. Mehrotra R, Singh M, Gupta RK, Singh M, Kapoor AK: Trends of prevalence and pathological spectrum of head and neck cancers in North India. Indian Journal of Cancer 2005, 42(2). 3. Hancock PJ, Epstein JB, Sadler GR: Oral and dental management related to radiation therapy for head and neck cancer. J Can Dent Assoc 2003, 69(9):585-590. 4. Dreizen S, Daly TE, Drane JB, Brown LR: Oral complications of cancer radiotherapy. Postgrad Med 1977, 61(2):85-92 10.1080/00325481.1977.11712115. 5. Marx RE: Osteoradionecrosis: a new concept of its pathophysiology. J Oral Maxillofac Surg 1983, 41(5):283-288 10.1016/0278-2391(83)90294-x. 6. Silverman Jr S, Chierici G: Radiation Therapy of Oral Carcinoma I. Effects on Oral Tissues and Management of the Periodontium. The Journal of Periodontology 1965, 36(6):478-484 https://doi.org/10.1902/jop.1965.36.6.478. 7. Yusof ZW, Bakri MM: Severe progressive periodontal destruction due to radiation tissue injury. J Periodontol 1993, 64(12):1253-1258 10.1902/jop.1993.64.12.1253. 8. Kassim N, Sirajuddin S, Biswas S, Rafiuddin S, Apine A: Iatrogenic Damage to the Periodontium Caused by Radiation and Radiotherapy. The Open Dentistry Journal 2015, 9:182-186 10.2174/1874210601509010182. 9. Marx RE, Johnson RP: Studies in the radiobiology of osteoradionecrosis and their clinical significance. Oral Surg Oral Med Oral Pathol 1987, 64(4):379-390 10.1016/0030-4220(87)90136-8. 10. Epstein JB, Corbett T, Galler C, Stevenson-Moore P: Surgical periodontal treatment in the radiotherapy-treated head and neck cancer patient. Spec Care Dentist 1994, 14(5):182-187 10.1111/j.1754-4505.1994.tb01129.x. 11. Llory H, Dammron A, Gioanni M, Frank RM: Some population changes in oral anaerobic microorganisms, Streptococcus mutans and yeasts following irradiation of the salivry glands. Caries Res 19
- DERIVEDAbou-Bakr A, Ahmed E, William H, Hassanein FEA. Frequency of periodontal disease in head and neck cancer patients after radiation therapy: a cross-sectional study. BMC Oral Health. 2025 Jul 2;25(1):1008. doi: 10.1186/s12903-025-06391-7. PMID 40604898