Clinical trial · Interventional
Effect of Coenzyme Q10 Administration on Polycystic Ovary Syndrome
The Effect of Coenzyme Q10 Supplementation on Oxidative Stress, Inflammation and Hyperandrogenism in Women with Polycystic Ovary Syndrome
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to determine the effects of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome. The main questions it aims to answer are: Does Coenzyme Q10 alter oxidative stress, inflammation and hyperandrogenism in women with Polycystic ovary syndrome. Participants will take Coenzyme Q10 200mg, once daily for a period of 3 months. The participants will be reassessed after 12 weeks by measuring Malondialdehyde MDA, C-reactive protein CRP, Sex hormone binding globulin SHBG.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovarian Syndrome (PCOS) | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Coenzyme Q10 | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- CoQ-10 supplementation
- description
- The experimental arm will consist of fertile females diagnosed with polycystic ovary syndrome aged between 18 to 50 years. Patients with diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function, autoimmune and Inflammatory disorders will be excluded.
- interventionNames
- Dietary Supplement: Coenzyme Q10
Primary outcomes (2)
- measure
- effect of coenzyme q10 administration on polycystic ovary syndrome
- timeFrame
- from enrollment to the end of treatment at 12 weeks
- description
- Improvement in levels of oxidative stress , inflammatory and hyperandrogenism biomarkers in women with Polycystic ovary syndrome
- measure
- The effect of coenzyme Q10 supplementation on oxidative stress, inflammation and hyperandrogenism in women with polycystic ovary syndrome
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Married Patients that presented with anovulatory infertility due to PCOS. * Unmarried Patients that presented with symptoms due to PCOS * All patients should fulfill Rotterdam criteria for PCOS Exclusion Criteria: * Male factor infertility ( oligospermia or aspermia) * Tubal factor infertility (abnormal hysterosalpingography) * Diabetes mellitus, thyroid dysfunction, cardiovascular diseases, impairment of hepatic and renal function * Autoimmune and Inflammatory disorders * Abnormal serum prolactin level * Smokers * Alcoholic beverage use * Use of anti diabetic, anti-obesity drugs, insulin or vitamin and mineral supplements
References
Publications (1)
- BACKGROUNDHu X, Wang W, Su X, Peng H, Tan Z, Li Y, Huang Y. Comparison of nutritional supplements in improving glycolipid metabolism and endocrine function in polycystic ovary syndrome: a systematic review and network meta-analysis. PeerJ. 2023 Nov 13;11:e16410. doi: 10.7717/peerj.16410. eCollection 2023. PMID 38025704