Clinical trial · Interventional
Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients
Effects of a Strength Physical Exercise Program in Chronic Lymphocytic Leukemia Patients on Quality of Life, Mental Health, and Frailty.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chronic lymphocytic leukemia (CLL) is a hematological neoplasm that primarily affects older individuals and is the most common type of leukemia in adults in Western countries. CLL mainly affects older adults, with an average age at diagnosis of around 70 years, and there is a slightly higher risk in men compared to women. It is characterized by the proliferation of clonal B lymphocytes in peripheral blood, bone marrow, and lymphoid organs. Although CLL has a relatively slow progression in many cases, patients may experience chronic fatigue, muscle weakness, functional impairment, and psychological disorders, such as anxiety and depression, which significantly affect their quality of life. In this context, it has been shown that physical exercise, especially strength training, can considerably improve physical and psychological conditions in oncology populations, such as those with breast cancer and colorectal cancer, as well as in older adults, where the benefits of resistance training are widely recognized. These benefits include increased muscle strength, reduced fatigue, improved functional abilities, psychological well-being, and overall quality of life. Furthermore, there is evidence that exercise can reduce systemic inflammatory markers, such as C-reactive protein (CRP), and improve lipid profiles by lowering total cholesterol and triglycerides, which is crucial for cancer patients at risk of cardiovascular diseases.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Lymphocytic Leukemia | Chronic Lymphocytic Leukemia | ONTOLOGY_EXACT | 0.98 |
| Exercise | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Exercise | Other | — | UNRESOLVED |
| Home exercise | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention Group (Therapeutic Strength Exercise Program):
- description
- The therapeutic strength exercise program focused on strength exercises, although daily aerobic exercises were also included. The intervention group will participate in a supervised therapeutic strength exercise program twice a week, combined with a physical activity promotion program to be conducted at home three days a week. All supervised strength exercise sessions will be led by a physiotherapist in a physiotherapy clinic with appropriate space for the intervention.
- interventionNames
- Other: Exercise
- type
- ACTIVE_COMPARATOR
- label
- Control Group (CG), group without an exercise program
- description
- Patients in the control group (CG) will only participate in the physical activity promotion program five days a week. This will be combined with walking for 60 minutes every day of the week.
- interventionNames
- Other: Home exercise
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria * Participants diagnosed with CLL or Small Lymphocytic Lymphoma (SLL) undergoing active treatment. * Participants who have not engaged in regular physical activity in the past 8 weeks. * Performance Status (ECOG) 0-1. * Signed informed consent. Exclusion Criteria * The presence of any medical contraindications to physical exercise, such as severe musculoskeletal disorders, serious cardiovascular diseases, bone metastases, or other conditions as determined by a healthcare professional. * Participants unable to complete the initial evaluation tests or who have difficulty performing basic exercises. * Other circumstances, as determined by the researchers, that may interfere with the study's objectives or development. Participants will be discontinued if they meet any of the following: * Negative developments or progression of the tumor process. * Severe adverse events related to exercise. * Voluntary withdrawal from the intervention. * New medical contraindications that prevent safe participation. * Non-adherence to the intervention protocol that compromises study integrity.
References
Publications (2)
- BACKGROUNDBrown JC, Spielmann G, Yang S, Compton SLE, Jones LW, Irwin ML, Ligibel JA, Meyerhardt JA. Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi-centre factorial randomized trial. J Cachexia Sarcopenia Muscle. 2024 Aug;15(4):1520-1527. doi: 10.1002/jcsm.13509. Epub 2024 Jun 18. PMID 38887915
- DERIVEDSanchez-Gonzalez JL, Fernandez-Rodriguez EJ, Mendez-Sanchez R, Polo-Ferrero L, Puente-Gonzalez AS, de Ramon C, Marcos-Asensio S, Blazquez-Benito P, Navarro-Bailon A, Sanchez-Guijo F, Martin-Sanchez C. Effects of a strength physical exercise program in chronic lymphocytic leukemia patients on quality of life, mental health, and frailty: a randomized controlled trial study protocol. Front Sports Act Living. 2025 Mar 10;7:1534861. doi: 10.3389/fspor.2025.1534861. eCollection 2025. PMID 40129522