Clinical trial · Interventional
Pelvis Adaptive Radiotherapy (ART)
Pelvis Adaptive Radiation Therapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pelvis Adaptive radiotherapy (ART) is a two phase study looking at using adaptive radiotherapy to help reduce toxicity for cancer patients having radiotherapy in the pelvic region. Adaptive radiotherapy is a new technology that provides the ability to account for daily changes in anatomy. Adaptive radiotherapy also provides a foundation for which radiotherapy margins might be safely reduced. Phase 1 of this study is looking to see if a radiation therapist centred adaptive workflow can be implemented. If phase 1 of this study is safe and feasible, the study will proceed to phase 2. Phase 2 of the study looks at using adaptive technology to reduce radiation treatment margins. The primary aim of this study is to see whether margin reduced treatment using adaptive radiotherapy can reduce side effects for patients with cancer in the pelvic area.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pelvis Neoplasms | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adaptive radiotherapy +/- margin reduction | Radiation | — | UNRESOLVED |
| Image guided radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Adaptive radiotherapy +/- margin reduction
- description
- Phase 1 and 2: Treating Radiation Therapists (RTs) on the treatment machine will review the treatment target and organs at risk contours that are automatically generated on the plan of the day. They will modify these safely, as required, and then also approve the computer generated re-plan of the day, within the bounds of departmental protocols and decision guides (RT led). Phase 2 only: Margin reduction facilitated by adaptive radiotherapy.
- interventionNames
- Radiation: Adaptive radiotherapy +/- margin reduction
- type
- ACTIVE_COMPARATOR
- label
- Standard radiotherapy
- description
- Patients will receive standard image guided radiotherapy
- interventionNames
- Radiation: Image guided radiotherapy
Primary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Age \> 18 2. ECOG performance status 0-2 3. Patients receiving curative or adjuvant pelvic radiation including: 1. Prostate cancer where nodal treatment is required 2. Prostate cancer post prostatectomy 3. Bladder cancer 4. Rectal cancer 5. Anal cancer 6. Adjuvant radiotherapy for gynaecological cancers 7. Pelvic Lymph nodes only 4. Ability to understand and the willingness to sign an informed consent Exclusion Criteria: * Hip prosthesis * Patient separation from approximate radiation centre to skin edge \> 24cm, measured on diagnostic scan
References
Publications (0)
Data not yet available