Clinical trial · Interventional
Impact of Different Carbohydrate Feedings on a Hydrogen Breath Curve and Self-reported Gastrointestinal Complaints
Hydrogen Breath Test Results After Consuming Fructose at Baseline and After Protein Supplementation
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
GI distress is widely prevalent among athletes, ranging from 30 to 90% in recreationally and professionally active athletes. As the recipient of nutrients, the gastrointestinal (GI) tract plays an important role in athleticism. The following pilot project aims to better understand if a fructose load after hiking under heat stress will result in a meaningful hydrogen breath elevation as a marker for malabsorption in healthy participants, and if supplementation of a multi-ingredient fermented whey supplement will result in a different hydrogen breath response rate after a heat stress hiking test.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Quality of Life | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Supplementation with a multi-ingredient whey supplement | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Baseline exercise tests with carbohydrate feeding and after supplementation
- description
- This arms includes the assessment for difference between two different boluses of carbohydrate after a hiking test in the heat on fructose malabsorption measured by determining a hydrogen breath curve, as well as taking multiple self-reported gastrointestinal symptom ratings during exercise test 1 and 2. In addition, this arm will assess hydrogen breath response and gastrointestinal symptom ratings (using one of the previously determined carbohydrate boluses) after supplementing a multi-ingredient whey protein for 3 weeks, followed by 2 more weeks of supplementation.
- interventionNames
- Dietary Supplement: Supplementation with a multi-ingredient whey supplement
Primary outcomes (1)
- measure
- Hydrogen breath curve
- timeFrame
- Measurements will be taken at -65 min before exercise, directly after exercise at 0 min, and at 30/120/150 and 180 min).
- description
- Fructose malabsorption will be determined by creating a hydrogen breath curve for each test day.
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Healthy subjects living in the United States. * Women/Men aged between 18-60 years (50-50%). * BMI value between ≥18.5 and ≤ 30 kg/m2. * No physical limitations (i.e., able to perform all activities associated with daily living in an independent manner). * Written informed consent. * Completed PAR-Q+ without any "yes" responses. * If currently using chronically or intermittently, willing to stop taking pre- and probiotics beginning 1 month prior to and throughout data collection. * If currently using chronically or intermittently, willing to stop using laxatives or fiber supplements, antacids and prokinetics beginning 1 month prior to and throughout data collection. Exclusion Criteria: * Smoking. * Clinical or self-perceived lactose intolerance. * Clinical or self-perceived milk protein allergy. * Diagnosed GI tract disorders or diseases. * Musculoskeletal disorders. * Diagnosed metabolic disorders (such as diabetes). * Use of any medications known to affect protein metabolism (i.e., corticosteroids, non-steroidal anti-inflammatories, or prescribed acne medications). * Chronic use of gastric acid suppressing medication or anti-coagulants. * Chronic use of anti-inflammatory medication. * Unwilling to stop taking pre- and probiotics beginning 1 month prior to and throughout data collection. * Unwilling to stop using laxatives or fiber supplements, antacids and prokinetics beginning 1 month prior to and throughout data collection.
References
Publications (0)
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