Clinical trial · Interventional
Effect of High Protein ONS on Older Gastric Cancer Patients Receiving Neoadjuvant Chemotherapy
Effect of High Protein Nutritional Supplementation on Nutritional Status, Functional Capacity and Quality of Life in Older Patients With Gastric Cancer Receiving Neoadjuvant Chemotherapy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This interventional prospective randomized controlled study was conducted to compare the effects of high-protein oral nutritional supplement (ONS) and medical nutritional therapy to medical nutrition therapy alone on nutritional status, quality of life, and physical function capacity after neoadjuvant chemotherapy in patients aged 65 and over with newly diagnosed locally advanced gastric cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Locally Advanced Gastric Adenocarcinoma | Gastric Adenocarcinoma | CURATED_BROADER | 0.78 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| oral nutritional supplement | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- ONS and standard nutrition support
- description
- Patients receiving high protein containing oral nutritional supplement with standart nutritional support
- interventionNames
- Dietary Supplement: oral nutritional supplement
- type
- NO_INTERVENTION
- label
- standart nutrition support
- description
- Patients receiving only standart nutritional support
Primary outcomes (5)
- measure
- Change in Mini Nutritional Assessment (MNA) score
- timeFrame
- Baseline and 8 Weeks
- description
- Unit of Measure: MNA score (Units on a Scale). This will measure changes in nutritional status using the MNA scoring system, which ranges from 0 to 30. A higher score indicates better nutritional status (24-30: normal nutritional status, 17-23.5: at risk of malnutrition, \<17: malnourished).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * • Aged 65 years or older. * Newly diagnosed histological confirmed locally advanced gastric cancer (Stage IIa to IIIa). * Scheduled to receive Neoadjuvant chemotherapy. * ECOG performance status of 0-2. * Signed informed consent to participate Exclusion Criteria: * Severe comorbidities affecting survival within 3 months. * Inability to comply with study procedures. * Previous gastric surgery or chemotherapy. * Metastatic dissease (Stage IV) * Poor performance status (ECOG 3-4) * Early satge (Stage I)
References
Publications (1)
- DERIVEDDogan Akagunduz D, Turker PF, Akagunduz B. Effects of high-protein nutritional supplementation on nutritional status, physical function, and quality of life in older gastric cancer patients receiving neoadjuvant chemotherapy: a randomized trial. Support Care Cancer. 2025 Aug 9;33(9):775. doi: 10.1007/s00520-025-09822-x. PMID 40782206