Clinical trial · Interventional
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars
Effect of Targeted Endodontic Microsurgery on Quality of Life and Healing on Mandibular Molars : A Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 18, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260918-000001
Summary
Brief summary (as posted)
Targeted endodontic microsurgery represents precise and advanced approach to resolving persisting chronic periapical periodontitis after non- surgical root canal treatment. This specialised procedure involves accessing the root tip of the tooth under high magnification using dental operating microscopes and employing microsurgical instruments to remove infected or inflamed tissue, as well as any pathological lesions present in the periapical region. Targeted Endodontic Microsurgery is useful for osteotomy and root- end resection when exacting control of depth, diameter, and angulation of osteotomy and root end resection is necessary. Using a CBCT(cone beam computed tomography) designed 3D - printed surgical guideis a more accurate method for access to the apical portion of the root during surgical endodontics compared with a "freehand" CBCT - approximated conventional method. These guided have the potential to increase accuracy and precision and to reduce intraoperative time as well as postoperative complications. Additionally, it provides a viable treatment option for patients who may not be candidates for traditional root canal therapy or retreatment due to anatomical complexities or previous treatment failures.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Endodontic Microsurgery | — | UNRESOLVED | — |
| Periapical Cyst | — | UNRESOLVED | — |
| Periapical Diseases | — | UNRESOLVED | — |
| Periapical Granuloma | — | UNRESOLVED | — |
| Periapical Pathology | — | UNRESOLVED | — |
| Periapical Periodontitis | — | UNRESOLVED | — |
| Targeted Endodontic Microsurgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis | Procedure | — | UNRESOLVED |
| Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Targeted Endodontic Microsurgery using trephine drill and 3d printed surgical guide
- description
- Endodontic Microsurgery using 3d printed static surgical guide using patient's cbct data
- interventionNames
- Procedure: Targeted Endodontic Microsurgery Using 3d Printed surgical guide using the patient's CBCT data
- type
- ACTIVE_COMPARATOR
- label
- Conventional Endodontic microsurgery using burs
- description
- Conventional Endodontic microsurgery using carbide bur and free hand conventional procedure
- interventionNames
- Procedure: Conventional Endodontic Microsurgery with a free hand procedure using bur and CBCT analysis
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 55 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with persistent symptomatic Or asymptomatic apical periodontitis and periapical radiolucency. * Previous history of Root canal retreatment. * Tooth with a peri-radicular lesion of strictly endodontic origin KIM's Classification A,B,C) * Patients between 18-55 years of age. * No general medical contraindications for oral surgical procedures (ASA-1) according to the classification of the American Society of Anesthesiologists) * ASA 1- A normal healthy patient. Example: Fit, nonobese (BMI under 30), nonsmoking, patient with good exercise tolerance. * Tooth with adequate final restoration without clinical evidence of coronal leakage. * No spontaneous pain or swelling. * Good periodontal health condition at tooth level * Able to completely understand and sign an informed consent form Exclusion Criteria: * Patients with systemic diseases (diabetes mellitus, uncontrolled hypertension grade III, hepatic/renal disease, or systemic bleeding disorders) * Patients on anticoagulant/ antiplatelet drugs. * Fractured/perforated teeth. * Teeth with deep pockets (probing depth \> 4 mm). * Presence of vertical root fracture. * Miller class III/IV mobility. * Pregnancy. * second mandibular molars
References
Publications (0)
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