Clinical trial · Observational
Human Papillomavirus Association and Genomic Exploration in Head-Neck Squamous Cell Carcinomas
Exploration of Human Papillomavirus Association and Genomic Characteristics in Head and Neck Squamous Cell Carcinomas in Bangladesh
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Head and neck squamous cell carcinoma (HNSCC) represents a significant public health burden in Bangladesh with a high incidence and mortality rate. While traditional risk factors like tobacco and betel nut chewing contribute to HNSCC incidence, the emergence of HPV-associated HNSCC presents a unique challenge. The main goal of this observational study is to explore the prevalence, risk factors, and biological mechanisms underlying food habits and HPV-driven HNSCC in the population and identify the genomic changes and characteristics related to this malignancy. This study will provide the prevalence of HPV-associated HNSCC and screening the HPV typing in the Bangladeshi population, identify risk factors, and any biologically driven mechanisms causing HNSCC.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head Neck Cancer | Head and Neck Neoplasm | PROBABILISTIC | 0.70 |
| Oropharyngeal Neoplasms | Oropharyngeal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- HPV Positive HNSCC Population
- description
- Tissues from Head Neck Squamous Cell Carcinoma and HPV DNA-positive
- interventionNames
- Diagnostic Test: Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing
- label
- HPV Negative HNSCC Population
- description
- Tissues from Head Neck Squamous Cell Carcinoma and HPV DNA-negative
- interventionNames
- Diagnostic Test: Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing
- label
- Healthy Population
- description
- Healthy Population who does not have any carcinoma, chronic diseases, Genetic diseases, acute/chronic infectious diseases, etc.
- interventionNames
- Diagnostic Test: Histopathology, Immunohistochemistry, Real-Time PCR, Sequencing
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patient Age: adult (\> 18 years) 2. Head and neck squamous cell carcinoma diagnosed by biopsy (Histopathology confirmed HNSCC). 3. Diagnosed cases specific Head-Neck sub-sites: (oral cavity, oropharynx, hypopharynx, larynx, tongue) 4. Patient's Consent Exclusion Criteria: 1. Patient Age: children (\< 18 years) 2. Cancers of any part of the body other than the head-neck region. 3. People without HNSCC 4. Any chronic diseases, genetic diseases, acute/chronic infectious diseases, etc. -
References
Publications (4)
- BACKGROUNDAkhter M, Ali L, Hassan Z, Khan I. Association of human papilloma virus infection and oral squamous cell carcinoma in Bangladesh. J Health Popul Nutr. 2013 Mar;31(1):65-9. doi: 10.3329/jhpn.v31i1.14750. PMID 23617206
- BACKGROUNDGao G, Wang J, Kasperbauer JL, Tombers NM, Teng F, Gou H, Zhao Y, Bao Z, Smith DI. Whole genome sequencing reveals complexity in both HPV sequences present and HPV integrations in HPV-positive oropharyngeal squamous cell carcinomas. BMC Cancer. 2019 Apr 11;19(1):352. doi: 10.1186/s12885-019-5536-1. PMID 30975103
- BACKGROUNDLechner M, Frampton GM, Fenton T, Feber A, Palmer G, Jay A, Pillay N, Forster M, Cronin MT, Lipson D, Miller VA, Brennan TA, Henderson S, Vaz F, O'Flynn P, Kalavrezos N, Yelensky R, Beck S, Stephens PJ, Boshoff C. Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors. Genome Med. 2013 May 29;5(5):49. doi: 10.1186/gm453. eCollection 2013. PMID 23718828
- BACKGROUNDShaikh MH, Khan AI, Sadat A, Chowdhury AH, Jinnah SA, Gopalan V, Lam AK, Clarke DTW, McMillan NAJ, Johnson NW. Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh. BMC Cancer. 2017 Nov 25;17(1):792. doi: 10.1186/s12885-017-3789-0. PMID 29178862